Fig. 9

Sirolimus and rosuvastatin attenuate STAT3 phosphorylation in the chronic stage. A–C Protein levels of STAT3 and p-STAT3 were determined via western blot analysis. Data are presented as the mean ± standard error of mean. Statistical significance was determined using Fisher’s least significant difference test (*p < 0.05, **p < 0.01, ***p < 0.001). SIR + RSV combination of sirolimus and rosuvastatin, STAT3 signal transducer and activator of transcription 3, p-STAT3 phosphorylated STAT3