Fig. 4
From: Selective SERCA2a activator as a candidate for chronic heart failure therapy
Modulation of electrical activity in healthy guinea pig myocytes. The effect of 1 μM compound 8 was tested on action potential (AP) parameters and their steady-state rate dependency in guinea pig myocytes. A Effect on the rate dependency of AP duration (APD50 and APD90), diastolic potential (Ediast) and maximal phase 0 velocity (dV/dtmax); n = 13 w/o compound 8, n = 11 with compound 8. B Effect on the time constant (τ) of APD90 adaptation following a step change in rate. 4 Hz: n = 9 w/o compound 8, n = 10 with compound 8; 2 Hz: n = 11 with or w/o compound 8. C Effect on the correlation between STV of APD90 and APD90 values; data from 1, 2 and 4 Hz were pooled