Fig. 3
From: Selective SERCA2a activator as a candidate for chronic heart failure therapy
Modulation of SR Ca2+ uptake under NCX inhibition in V-clamped STZ myocytes. SR Ca2+ loading by a train of V-clamped pulses was initiated after caffeine-induced SR depletion; NCX was blocked by Na+ substitution to identify SERCA2a-specific effects (see Methods and Additional file 1: Figure S1). Panels from left to right: CaT amplitude, excitation-release (ER) gain (the ratio between CaT amplitude and Ca2+ influx through ICaL), time constant (τ) of CaT decay; STZ N = 3 (n = 18 w/o compound 8, n = 23 with compound 8). *p < 0.05 for the interaction factor in RM two-way ANOVA, indicating a different steepness of curves