Fig. 4

Case study on colorectal cancer. A Integrated similarity matrix for 297 patients with CRC. Clusters (CS1-CS3) are ordered by spectral clustering labels from integrated network and reveal relatively stronger inter-cluster similarity. B Kaplan–Meier curves of disease-free survival for the subtypes identified using MOSD (p = 3.11E-4, log-rank test). C The identified subtypes (CSs1-3) show significantly associated with some common mutations (*0.05; **0.01; ***0.001). D Gene set enrichment analysis using mRNA expression. The MOSD subtypes reflect different interests in some signatures or pathways