Fig. 4

Germinal center-associated B-cell subtypes present in MIBC. A Heatmap shows GSVA scores of enriched germinal center-associated gene sets. B tSNE plot showing the expression densities of the LMO2, AICDA, and NEIL1 genes in B-cell subtypes. C The Gene Ontology (GO) terms of genes that exhibited significant enrichment in B-LMO2 (top) and B-STMN1 (bottom) were determined through the application of Fisher's test for statistical analysis. D RNA velocity of B-cell subtypes. It shows the transformation of B-cell subtypes. E Box plot showing the proportions of B-LMO2 (left) and B-STMN1 (right) in MIBC, NMIBC, normal tissue, PBMC, and lymph node samples