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Table 2 Univariate and multivariable analyses of predictors of LNM in the training cohort

From: Association of the pathomics-collagen signature with lymph node metastasis in colorectal cancer: a retrospective multicenter study

Variables

Univariate analysis

Multivariable analysis

OR (95% CI)

P

OR (95% CI)

P

Age

0.985 (0.968, 1.003)

0.104

  

Sex

    

 Male

Ref.

   

 Female

1.023 (0.659, 1.587)

0.920

  

Primary tumor location

    

 Left-sided

Ref.

   

 Right-sided

1.042 (0.656, 1.655)

0.860

  

Preoperative CEA level

    

 Normal

Ref.

 

Ref.

 

 Elevated

2.105 (1.342, 3.302)

0.001

2.109 (1.010, 4.405)

0.047

Preoperative CA19-9 level

    

 Normal

Ref.

   

 Elevated

1.417 (0.851, 2.358)

0.180

  

Lymphadenectasis on CT

    

 < 10 mm

Ref.

 

Ref.

 

 ≥ 10 mm

4.381 (2.736, 7.015)

 < 0.001

3.816 (1.834, 7.943)

 < 0.001

Tumor differentiation

    

 Well or moderately

Ref.

   

 Poorly or undifferentiated

1.583 (0.918, 2.732)

0.099

NA

NA

VELIPI

    

 No

Ref.

 

Ref.

 

 Yes

3.074 (1.949, 4.848)

 < 0.001

2.198 (1.067, 4.572)

0.033

Tumor size, cm

    

 < 4

Ref.

   

 ≥ 4

1.182 (0.762, 1.833)

0.455

  

pT stage

    

 pTis-T2

Ref.

 

Ref.

 

 pT3

2.262 (1.208, 4.237)

0.011

3.239 (1.156, 9.080)

0.025

 pT4

4.135 (2.153, 7.941)

 < 0.001

4.162 (1.396, 12.411)

0.011

PCS

7.943 (4.521, 13.955)

 < 0.001

8.014 (4.266, 12.140)

 < 0.001

  1. OR odds ratio, CI confidence interval, VELIPI venous emboli and/or lymphatic invasion and/or perineural invasion, NA not available, Ref reference, PCS pathomics-collagen signature
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Journal of Translational Medicine

ISSN: 1479-5876

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