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Table 1 Univariate and multivariate cox analysis of disease-free survival and overall survival in the Zhongshan dataset

From: DeepRisk network: an AI-based tool for digital pathology signature and treatment responsiveness of gastric cancer using whole-slide images

Variables

Overall survival

Disease-free survival

Univariate

Multivariate

Univariate

Multivariate

HR

95% CI

P

HR

95% CI

P

HR

95% CI

P

HR

95%

P

Age (>60 vs ≤60 years)

1.32

1.01–1.73

0.043

1.18

0.89–1.55

0.245

1.11

0.91–1.34

0.306

   

Sex (Female vs male)

0.79

0.59–1.08

0.136

   

0.80

0.65–1.00

0.045

0.94

0.76–1.17

0.60

Tumor location

1.05

0.88–1.25

0.582

   

0.90

0.80–1.02

0.099

   

Tumor size (>4 vs≤4)

2.74

2.09–3.59

<0.0001

2.11

1.49–2.99

<0.0001

2.11

1.74–2.56

<0.0001

1.33

1.09–1.63

0.005

Lauren type

1.18

1.00–1.40

0.047

1.05

0.88–1.25

0.61

1.06

0.94–1.20

0.303

   

LVI (positive vs negative)

2.31

1.74–3.06

<0.0001

1.39

1.03–1.87

0.030

1.92

1.57–2.33

<0.0001

1.26

1.02–1.55

0.029

PNI (positive vs negative)

2.45

1.80–3.33

<0.0001

1.44

1.03–2.00

0.031

2.13

1.72–2.64

<0.0001

1.28

1.01–1.61

0.040

TNM stage (III–IV vs I–II)

5.09

3.57–7.26

<0.0001

2.72

1.83–4.05

<0.0001

3.91

3.11–4.91

<0.0001

2.50

1.93–3.23

<0.0001

Tumor differentiation (Undifferentiated vs differentiated)

1.03

0.79–1.35

0.83

   

0.80

0.66–0.97

0.024

0.69

0.57–0.84

0.0002

DPS (high vs low)

7.12

4.69–10.81

<0.0001

5.41

3.55–8.24

<0.0001

2.58

2.09–3.18

<0.0001

1.97

1.59–2.44

<0.0001

  1. LVI, Lymphovascular invasion; PNI, Peripheral nerve invasion; DPS, digital pathology signature; TNM, tumor, node, and metastasis