Fig. 1

Surface CAR expression is more dramatically down-regulated when exposed to U937 myeloid leukemia cells A–C, Surface CD33, CLL-1, and CD123 CAR expression and cytotoxicity of CAR T cells that cocultured with Nalm6^CD33 or U937^CD33, Nalm6^CLL−1 or U937^CLL−1 cells, Nalm6^CD123 or U937^CD123 cells at different effector: target (E: T) ratios. Data shown are mean ± SEM of three experimental replicates. D, Surface CAR expression in NSG mouse model. A–D were representative data from at least three independent experiments with different donors. Assays were performed on day 10 after the initial T-cell culture. Unless otherwise noted, P values are determined by unpaired t-tests. The numbers on the graphs are P values