Fig. 4

LIPCAR levels are increased in EVs-isolated from plasma of MI patients with left ventricle remodelling (LVR). A, B Nanoparticle tracking analysis (NTA) of EVs isolated from plasma of MI patients with (LVR) or without LVR (no LVR) (n = 5/group). Size distribution (A) and concentration (B) of lEVs (top) and sEVs (bottom). C Quantification by qRT-PCR of LIPCAR levels in plasma-derived lEVs (top) and sEVs (bottom). The synthetic miR-cel39 was added during RNA extraction and used to normalize LIPCAR levels. D Graphs showing the levels of LIPCAR in lEV (top) or sEV (bottom) after normalization by particles concentration of each sample. E Correlation between LVR and LIPCAR levels in plasma-derived lEVs (top) and s-EVs (bottom). Statistical significance was determined by Wilcoxon-Mann Whitney test or Spearman test and only significant P values are indicated