Fig. 6

Cell–cell communication between the 9 tumor cell clusters in ccRCC tissues. A. The heatmap showing the top 11 signals in the 9 tumor cell clusters with the largest contribution of outgoing or incoming signals. B. Dot plot showing 11 signals divided into 4 groups of signal modules based on functional similarity. C. Heatmap depicting network centrality scores for the MIF signaling; bar graph showing L-R pairs that mediate communication in the MIF signaling pathway; violin plots illustrating the expression of receptor-ligand pairs of the MIF signaling pathway. D–F. Figures displaying network centrality scores (heatmaps), ligand-receptor pairs mediating communication (bar graphs), and expression of receptor-ligand pairs (violin plots) for ANGPTL, SPP1, and VISFATIN signaling pathways. G. River diagrams showing the communication patterns that coordinate secretory cell clusters and outgoing signaling pathways, as well as those that coordinate target cell clusters and incoming signaling pathways