Fig. 6

scAAV2-DX2 has a therapeutic effect in rotenone-induced parkinsonism mice A scheme of the therapeutic model of rotenone-induced Parkinson’s disease using scAAV2-DX2 B The pole test. C The rotarod test. scAAV2-DX2 recovered motor coordination and balance in the rotenone-treated PD mouse model. D Immunohistochemistry and immunofluorescence image of the mouse substantia nigra. The upper panel shows TH-positive cells in the striatum and the lower panel indicates the distribution of an injected-GFP expressing virus. The white scale bar represents 50 µm. Animals; n = 5 (in each group), ns, no significant; *, P < 0.05; ***, P < 0.001; t-test. E Schemic image of regulation of therapeutic viral genome