Fig. 1From: Matrix stiffness affects tumor-associated macrophage functional polarization and its potential in tumor therapyThe relationship between matrix stiffness and macrophage polarization in the TME. With the deposition of collagen and the increase in matrix stiffness in the TME, stiff ECM can polarize macrophages into tumor-promoting M2-type TAMs, which in turn also promotes the stiffness of the ECMBack to article page