Fig. 1

Potential direct effects of myocardial infarction (MI) on tumor growth and metastasis. An MI model was shown to promote colon, lung, and breast cancer growth. The MI condition also increased metastasis of breast cancer. Cardiac expression of SerpinA3, SerpinA1, and miR-22-3p were increased in MI models. The miR-22-3p was also increased in plasma and tumor tissue, resulting in attenuated breast cancer cell sensitivity to erastin-induced ferroptosis. MI also increased Ly6C^hi monocytes in plasma, tumor, and bone marrow, which led to an increased proportion of regulatory T-cells in the tumor microenvironment. Blue arrows indicate the changes of potential cardiokines and micro-RNAs. Red arrows indicate the effect of MI on tumor growth. The purple arrow indicates the change in ferroptotic cell death sensitivity. Figure created with BioRender.com