Table1 Transcription factors associated with CD8⁺ T cells

T-bet

Affect CD8⁺ T cells fate; promote INF-γ expression; depress IL-17 production; interaction with mTOR and IL-12

[17, 18, 22,23,24, 156]

Runx3

CTL proliferation; granzyme expression; interaction with T-bet and Eomes;

[43, 157]

Sox9

Negatively regulated CD8⁺ T cells

[158]

NFAT

Inhibition the production of cytokine

[159]

Eomes

Affect CD8⁺ T cells fate; the homeostasis of CD8⁺ T cells; IFN-α production; cytotoxicity; granzyme and perforin production; repress IL-17 and IL-12; interaction with mTOR

[19, 21, 34, 43, 156, 160]

c-Myc

The homeostatic proliferation of memory CD8⁺ T cells

[161]

Blimp-1

The homeostasis of CD8⁺ T cells; cytotoxicity; interaction with IL-2

[162, 163]

Bcl-6

The generation and maintenance of memory CD8⁺ T cells

[164]

NF-κB

The generation and maintenance of memory CD8 ⁺T cells; cytokine production

[165]

Notch

CD8⁺ T cells proliferation; INF-γ expression; expression of eomesodermin, perforin, and granzyme B

[166, 167]

STAT1/4

Cytotoxicity generation and promote INF-γ expression

[6, 168, 169]