Fig. 3
From: The expanding Pandora’s toolbox of CD8+T cell: from transcriptional control to metabolic firing
CD8+ T cell interaction with other immune cells in tumor microenvironment. A the check and balance between immune system and tumors. The three phases between immune system and tumors, elimination, equilibrium and escape, respectively. B CD8+ T cell in TME. There are a variety of cells and cytokines in TME, that crosstalk with each other to affect the function of CD8+ T cells, and M1 is tumor-suppressing, M2 is tumor-promoted. CD4 + T cell and DCs are stimulators for CD8+ T cells. C when immune system is out of control and defeated, then cancer outgrowth. M1 M1 type macrophages, M2 M2 type macrophages, DC dendritic cell, TME tumor microenvironment