Fig. 1
From: The expanding Pandora’s toolbox of CD8+T cell: from transcriptional control to metabolic firing
Transcriptional and epigenetic mechanisms involved in CD8+ T cell development. A APCs can recognize and present the antigens, and then present to CD8 + T cells by MHC, CD8 + T cells are activated. B When naive CD8+ T cells activated, most of them transform into effect CD8+ T cells and a small part transform into memory CD8+ T cells. Naive CD8+ T cells translate effector CD8+ T cells, this process is regulated by transcription factors, such as T-bet, and so on, at the same time, epigenetics is changed. C: memory CD8+ T cells can self-renew, and when it’s stimulated by second antigens, memory CD8+ T cells rapidly transform into effect CD8+ T cells. D: effect CD8+ T cells secrete cytokines such as TNFs in response to stimulation. APC antigen presenting cell; MHC major histocompatibility complex, TFs transcription factors, PD-1 programmed death receptor 1