Fig. 5

Gas6 played a key role in relieving gout pain with ozone. A Mechanical threshold of ipsilateral hind-paws between WT and Gas6-/- mice induced by MSU. B Ankle girth according to time after MSU crystal injection between WT and Gas6^−/− mice. C–I Ozone ameliorates the pain gait patterns of mice with MSU-treated. ^*p < 0.05, ^**p < 0.01 and ^***p < 0.001 vs. control group; ^#p < 0.05, ^##p < 0.01 and ^###p < 0.001 vs. MSU-treated group; ^&p < 0.05, ^&&p < 0.01 and ^&&&p < 0.001 vs. MSU + ozone group