Fig. 4

Ozone inhibited MMP9 activity through the MerTK/SOCS3 signal pathway to relieve gout. A Mechanical allodynia was performed to evaluate the effect of ozone after UNC2541 was treated. B Time course of changes in MSU-induced ankle swelling after UNC2541 was treated. C, D Western blot analysis showed the expression levels of MMP9 and SOCS3 after being treated with UNC2541 in the ankle joint. ^*p < 0.05, ^**p < 0.01 and ^***p < 0.001 vs. control group; ^#p < 0.05, ^##p < 0.01 and ^###p < 0.001 vs. MSU-treated group; ^&p < 0.05, ^&&p < 0.01 and ^&&&p < 0.001 vs. MSU + ozone group