Fig. 1
From: RUNX1 knockdown induced apoptosis and impaired EMT in high-grade serous ovarian cancer cells
The expression comparison of RUNX1 in ovarian cancer. The expression pattern of RUNX1 in ovarian tumor tissues and NT (normal tissues) (A), including 426 tumor tissues (TCGA) and 88 normal tissues (GTEx). The comparison of the expression level for RUNX1 mRNA was performed. OS (p = 0.0062, B) of ovarian cancer patients was significantly positively associated with the expression of RUNX1. Representative images are shown the expression of RUNX1 in normal ovarian tissues, mucinous ovarian cancer tissues, LGSOC (low grade serous ovarian cancer) tissues, HGSOC (high grade serous ovarian cancer) tissues and other types of ovarian cancer tissues (C). The IHC staining scores were statistically analyzed between normal and ovarian cancer tissues (D). The overexpression of RUNX1 was analyzed by western blot in normal ovarian epithelial cells and HGSOC cell lines (E and F)