Fig. 4

Molecular signatures associated to NOVA1, PRPF8 and SRSF10 expression in RNA-seq data from pulmonary carcinoids. A. Gene Set Enrichment Analysis (GSEA) using Hallmarks gene set to look for molecular pathways associated to NOVA1, PRPF8 and SRSF10 expression. Normalized Enrichment Score is represented for each of the pathways, being plotted only those pathways with p < 0.05. B, C, D. Volcano plots showing differential PSI of alternative splicing events against -log10 p value, when comparing high and low expression groups from NOVA1 (B), PRPF8 (C) and SRSF10 (D). Only statistically significant events are colored (p < 0.05). E. Bar plot showing the proportion of each of the alternative splicing event’s patterns to which belong the total events, NOVA1, PRPF8 and SRSF10 associated events