Fig. 1

The splicing machinery is profoundly dysregulated in lung carcinoids. A. Individual fold-change of the RNA expression levels of all the splicing machinery components analyzed in lung carcinoids FFPE samples [n = 23 (typical carcinoids, atypical carcinoids, and undetermined carcinoids)] compared with non-tumoral adjacent tissue [n = 24]. Data represents mean ± SEM. Asterisks indicate significant differences (* p < 0.05; **p < 0.01; ***p < 0.001). B. Partial least squares discriminant analysis (PLSDA) of the RNA expression levels of the splicing machinery components in the Discovery cohort. VIP scores obtained from PLSDA of the complete splicing machinery studied. C. Hierarchical heatmap generated with the expression levels of the top 10 genes of the splicing machinery that contribute most to the discrimination between tumor tissue (red) and adjacent non-tumor tissue (green)