Table 3 Core Gene Pathway Alterations and Association with Distal Metastasis

TP53

 WT

37/212 (17.5%)

1

1/35 (2.9%)

1

16/95 (16.8%)

1

20/82 (24.4%)

1

3/33 (9.1%)

1

 Missense

57/257 (22.2%)

0.203^†

8/39 (20.5%)

0.030^‡

23/103 (22.3%)

0.332^†

25/114 (21.9%)

0.686^†

0/9

–

 Truncating

20/114 (17.5%)

0.984^†

2/20 (10.0%)

0.546^‡

10/56 (17.9%)

0.873^†

8/38 (21.1%)

0.688^†

1/2

–

 Others^*

1/12 (8.3%)

0.413^‡

1/2

–

1/7 (14.3%)

0.861^‡

0/4

–

None

–

Mutated

78/383 (20.4%)

0.389^†

11/61 (18.0%)

^0.030‡

34/166 (20.5%)

0.472^†

33/156 (21.2%)

0.568^†

1/11 (9.1%)

1.000^‡

Cell cycle

 WT

92/485 (19.0%)

1

10/82 (12.2%)

1

36/206 (17.5%)

1

46/197 (23.4%)

1

4/41 (9.8%)

1

 Mutated

23/110 (20.9%)

0.642^†

2/14 (14.3%)

0.222^‡

14/55 (25.5%)

0.182^†

7/41 (17.1%)

0.379^†

0/3

–

TGFb

 WT

78/457 (17.1%)

1

8/80 (10.0%)

1

34/204 (16.7%)

1

36/173 (20.8%)

1

4/38 (10.5%)

1

 Mutated

37/138 (26.8%)

^0.011†

4/16 (25.0%)

0.098^‡

16/57 (28.1%)

0.053^†

17/65 (26.2%)

0.377^†

0/6

–

Mutated pathways

 0-1

75/424 (17.7%)

1

7/75 (9.3%)

1

30/182 (16.5%)

1

38/167 (22.8%)

1

4/39 (10.3%)

1

 2-3^**

40/171 (23.4%)

0.111^†

5/21 (23.8%)

0.076^‡

20/79 (25.3%)

0.096^†

15/71 (21.1%)

0.782^†

0/5

–

Trithorax

 WT

86/463 (18.6%)

1

9/84 (10.7%)

1

35/201 (17.4%)

1

42/178 (23.6%)

1

2/31 (6.5%)

1

 Mutated

29/132 (22.0%)

0.384^†

3/12 (25.0%)

0.162^‡

15/60 (25.0%)

0.190^†

11/60 (18.3%)

0.397^†

2/13 (15.4%)

0.570^‡

HRD

 WT

94/503 (18.7%)

1

8/83 (9.6%)

1

43/219 (19.6%)

1

43/201 (21.4%)

1

1/27 (3.7%)

1

 Mutated

21/92 (22.8%)

0.355^†

4/13 (30.8%)

0.032^‡

7/42 (16.7%)

0.654^†

10/37 (27.0)

0.449^†

3/17 (17.6%)

0.282^‡

MMRD

 WT

111/583 (19.0%)

1

12/96 (12.5%)

1

49/257 (19.1%)

1

50/230 (21.7%)

1

4/43 (9.3%)

1

 Mutated

4/12 (33.3%)

0.215^‡

None

–

1/4 (25.0%)

0.575^‡

3/8 (37.5%)

0.292^‡

0/1

–