Table 2 Core Gene Pathway Alterations and Association with Lymph Nodes Involvement

TP53

 WT

90/172 (52.3%)

1

8/34 (23.5%)

1

45/79 (57.0%)

1

37/59 (62.7%)

1

12/30 (25.0%)

1

 Missense

106/197 (53.8%)

0.776^†

17/31 (54.8%)

0.010^†

45/80 (56.3%)

0.928^†

44/86 (51.2%)

0.169^†

4/9 (40.4%)

0.812^‡

 Truncating

46/93 (49.5%)

0.656^†

5/18 (27.8%)

0.736^‡

23/46 (50.0%)

0.451^†

18/29 (62.1%)

0.953^†

1/1

–

 Others^*

6/11 (54.5%)

0.886^†

1/1

–

4/6

–

1/4

–

None

–

 Mutated

158/301 (52.5%)

0.972^†

23/50 (46.0%)

0.036^†

72/132 (54.5%)

0.732^†

63/119 (52.9%)

0.216^†

5/10 (50.0%)

0.580^‡

Cell cycle

 WT

202/387 (52.2%)

1

25/72 (34.7%)

1

92/170 (54.1%)

1

85/145 (58.6%)

1

15/37 (40.5%)

1

 Mutated

46/86 (53.5%)

0.828^†

6/12 (50.0%)

0.310^‡

25/41 (61.0%)

0.428^†

15/33 (45.5%)

0.169^†

2/3 (66.7%)

0.565^‡

TGFb

 WT

195/374 (52.1%)

1

26/72 (36.1%)

1

94/170 (55.3%)

1

75/132 (56.8%)

1

15/34 (44.1%)

1

 Mutated

53/99 (53.5%)

0.805^†

5/12 (41.7%)

0.712^‡

23/41 (56.1%)

0.926^†

25/46 (54.3%)

0.771^†

2/6 (33.3%)

1.000^‡

Mutated pathways

 0-1

180/344 (52.3%)

1

22/68 (32.4%)

1

84/152 (55.3%)

1

74/124 (59.7%)

1

16/35 (45.7%)

1

 2-3^**

68/129 (52.7%)

0.940^†

9/16 (56.3%)

0.075^†

33/59 (55.9%)

0.930^†

26/54 (48.1%)

0.154^†

1/5 (20.0%)

0.373^‡

Trithorax

 WT

202/374 (54.0%)

1

27/75 (36.0%)

1

100/166 (60.2%)

1

75/133 (56.4%)

1

10/29 (34.5%)

1

 Mutated

46/99 (46.5%)

0.181^†

4/9 (44.4%)

0.620^‡

17/45 (37.8%)

0.007^†

25/45 (55.6%)

0.922^†

7/11 (63.6%)

0.096^‡

WNT

 WT

232/430 (54.0%)

1

31/78 (39.7%)

1

106/187 (56.7%)

1

95/165 (57.6%)

1

17/38 (44.7%)

1

 Mutated

16/43 (37.2%)

0.036^†

0/6

–

11/24 (45.8%)

0.314^†

5/13 (38.5%)

0.181^†

0/2

–

Hedgehog

 WT

246/461 (53.4%)

1

31/81 (38.3%)

1

116/204 (56.9%)

1

99/176 (56.3%)

1

16/37 (43.2%)

1

 Mutated

2/12 (16.7%)

0.012^†

0/3

–

1/7 (14.3%)

0.046^‡

1/2 (50.0%)

1.000^‡

1/3 (33.3%)

1.000^‡