Fig. 4

TP53 knock-out was associated with lower invasiveness compared with TP53 missense mutations. A Transwell migration assay of PANC-1 and CFPAC-1 cells after knock-out of the TP53 missense mutation. B Wound healing assays performed using PANC-1 and CFPAC-1 cells after knock-out of the TP53 missense mutation. C Validation of the knock-out of the TP53 missense mutation by qRT-PCR.