Characterization of the proteome of stable and unstable carotid atherosclerotic plaques using data-independent acquisition mass spectrometry

Lai, Zhichao; Wang, Chaonan; Liu, Xiaoyan; Sun, Haidan; Guo, Zhengguang; Shao, Jiang; Li, Kang; Chen, Junye; Wang, Jiaxian; Lei, Xiangling; Shu, Keqiang; Feng, Yuyao; Kong, Deqiang; Sun, Wei; Liu, Bao

doi:10.1186/s12967-023-04723-1

Table 1 Demographic and clinical characteristics of the subjects

From: Characterization of the proteome of stable and unstable carotid atherosclerotic plaques using data-independent acquisition mass spectrometry

	Discovery cohort (n=88)	Unstable (n=49)	P value	Validation cohort (n=35)	Unstable (n=15)	P value
	Stable (n=39)	Unstable (n=49)	P value	Stable (n=20)	Unstable (n=15)	P value
Age (years)	65.73± 8.28	67.84±8.45	0.259^a	65.25±7.36	66.07±3.69	0.697^a
Weight (kg)	72.78±6.78	76.45±10.88	0.351^a	69.55±6.66	0.069	0.452^a
Gender (male, %)	86.486	80.000	0.824^b	90.000	73.333	0.367^b
Surgical side (%)			0.775^b			0.176^b
Left	43.243	46.667		60.000	33.333
Right	56.756	53.333		40.000	66.667
Degree of left carotid artery stenosis (%)			＜0.001^b			0.644^b
Mild	40.541	33.333		25.000	20.000
Moderate	29.731	13.333		15.000	33.333
Severe	27.027	42.222		60.000	46.667
Occlusion	2.703	11.111		0.000	0.000
Degree of right carotid artery stenosis (%)			0.319^b			0.245^b
Mild	24.324	28.889		35.000	13.333
Moderate	13.514	11.111		5.000	20.000
Severe	45.946	51.111		45.000	66.667
Occlusion	16.216	8.889		15.000	0.000
Hypertension (%)	72.973	64.444	0.283^b	75.000	73.333	>0.999^b
Diabetes (%)	37.838	48.889	0.151^b	30.000	26.667	>0.999^b
Hyperlipidemia (%)	35.135	24.444	0.121^b	90.000	76.667	0.182^b
Coronary heart disease (%)	27.027	24.444	0.745^b	35.000	33.333	>0.999^b
Smoking (%)	64.865	53.333	0.148^b	35.000	46.667	0.321^b
Cerebral infarction (%)	37.838	28.889	0.226^b	35.000	33.333	>0.999^b
Subclavian artery stenosis (%)	24.324	18.889	0.385^b	20.000	20.000	>0.999^b
Lower limb artery stenosis (%)	8.108	17.778	0.085^b	10.000	6.667	>0.999^b
Total cholesterol (mmol/L)	3.752	3.664	0.677	3.705	3.795	0.837
Triglycerides (mmol/L)	1.638	1.263	0.06	2.069	2.139	0.118
HDL-C (mmol/L)	0.994	1.008	0.773	0.963	1.083	0.248
LDL-C (mmol/L)	2.03	2.045	0.928	2.129	2.033	0.716
ApoA1 (g/L)	1.22	1.198	0.567	1.241	1.214	0.682
ApoB (g/L)	0.778	0.746	0.53	0.787	0.946	0.166
Lipoprotein(a) (mg/L)	205.8	212.5	0.909	159.1	312.5	0.094
hsCRP (mg/L)	2.779	3.502	0.575	1.92	2.894	0.340

^aTwo-sided p-value for numerical values were determined using unpaired multiple T-test
^bTwo-sided p-value for categories were calculated using Chi-square test and Fisher’s exact test. Data are presented as the mean ± standard deviation or number (%)
P value < 0.05 are indicated as significant

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