Table 3 Natural compounds targeting brast CAF

Resveratrol

Polyphenols

resveratrol inhibits CAF-CM-induced breast cancer cell migration and invasion by blocking cyclin D1 and c-Myc expression

Migration and invasion of breast cancer

[130]

Curcumin

Polyphenols

Reduces the secretion of IL-6, MMP2, MMP9, transforming growth factor-β and SDF-1; Upregulates the aging-related proteins P16, P21 and P53

Inhibits the invasion/migration of breast cancer cells and induces fibroblast aging

[135]

ECGG

Polyphenols

Reduce HGF in CAFs to inhibit tumor proliferation and invasion, and inhibit tumor metastasis by lowering VEGF

Proliferative, migratory and invasive tumors

[136]

Eugenol

Polyphenols

Eugenol downregulates DNMT1 and DNMT3A by inhibiting the migratory/invasion capacity of CAFs by inhibiting Erk1/2 and MMP-9

Migration, invasion and EMT of breast cancer

[137]

Eugenol

Polyphenols

Eugenol and decitabine inhibit paracrine proangiogenic effects of CAF cells by inhibiting DNMT1 and its downstream angiogenic effectors VEGF-A and IL-8

angiogenesis

[138]

Oroxylin A

Flavonoid

OA can inhibit phosphorylation of FAK/STAT3 by reducing the expression of ACTN1

Proliferative, migratory and invasive tumors

[139]

Puerarin

Flavonoid

Reduces intratumoral immunosuppressive cytokines (IL-4, IL-6, IL-10 and IL-13)

Downregulate CAFs to increase infiltrating T cells in tumors

[140]

Apigenin

Flavonoid

Apigenin can block the release of CCL2 in TNFα-mediated triple-negative breast cancer (TNBC) cell lines

Blocks the release of chemokines

[141]

Caffeine

Alkaloid

Caffeine inactivates CAFs cells via PTEN-dependent Erk1/2 and Akt inactivation

Migration, invasion and angiogenesisof breast cancer

[142]

Prunella Vulgaris Polysaccharide

PolysacchArides

PVP can exert anticancer effects on breast CAFs by inhibiting the expression of bFGF

Inhibits tumor growth, migration and angiogenesis

[111]

Cucurbitacine

Triterpenoid

Acts on breast CAFs by IL-6/STAT3/NF‐κB

Inhibits paracrine and angiogenesis

[134]

Atractylenolide-I

Lipid components

ATL-1 downregulates fibroblast expression of CTGF

Inhibits fibroblast transformation ability and increases chemotherapy sensitivity

[143]