Skip to main content

Table 2 Up-ubiquitination and down-ubiquitination modified by TRIM59

From: A role of TRIM59 in pulmonary hypertension: modulating the protein ubiquitylation modification

Gene symbol

Ubiquitination site

Fold change

Description

Up-ubiquitination modification

 

 ACSL4

K702

6.02

Long-chain-fatty-acid–CoA ligase 4

K401

28.94

 

 ACTB

K328

4.97

Actin, cytoplasmic 1

 AHCY

K188

2.24

Adenosylhomocysteinase

 AKAP2

K448

5.23

A-kinase anchor protein 2

 ALDOA

K42

2.33

Fructose-bisphosphate aldolase A

 ANKRD13A

K247

11.82

Ankyrin repeat domain-containing protein 13A

K219

7.93

 

 APBB1

K48

5.79

Amyloid beta precursor protein binding family B member 1

 CAVIN1

K170

17.71

Caveolae-associated protein 1

K122

9.64

 

 CCDC50

K129

1.43

Coiled-coil domain-containing protein 50

 CDC20

K490

6.30

Cell division cycle protein 20 homolog

 CHIC1

K176

5.05

Cysteine-rich hydrophobic domain-containing protein 1

 CLIC4

K199

1.94

Chloride intracellular channel protein 4

 CRIM1

K978

3.64

Cysteine-rich motor neuron 1 protein

 CSDE1

K91

3.37

Cold shock domain-containing protein E1

 CUEDC1

K318

2.31

CUE domain-containing protein 1

 CYB5R3

K163

3.92

NADH-cytochrome b5 reductase 3

 CYP1B1

K454

3.57

Cytochrome P450 1B1

 DAG1

K793

4.68

Dystroglycan 1

K782

31.67

 

 DCBLD2

K560

1.70

Discoidin, CUB and LCCL domain-containing protein 2

 EEF2

K272

8.43

Elongation factor 2

K239

1.66

 

 EHMT1

K827

3.33

Histone-lysine N-methyltransferase EHMT1

 EPS15L1

K531

3.80

Epidermal growth factor receptor substrate 15-like 1

 FADS2

K409

3.58

Acyl-CoA 6-desaturase

K28

22.75

 

K108

5.67

 

 GABARAP

K13

4.36

Gamma-aminobutyric acid receptor-associated protein

 GAPDH

K194

3.77

Glyceraldehyde-3-phosphate dehydrogenase

 GJA1

K303

16.95

Gap junction alpha-1 protein

K258

5.67

 

K128

7.89

 

 GNAI2

K46

2.26

Guanine nucleotide-binding protein G(i) subunit alpha-2

 GPRC5A

K348

4.93

Retinoic acid-induced protein 3

 GRB2

K109

1.92

Growth factor receptor-bound protein 2

 H1-5

K93

8.22

Histone H1.5

K88

2.86

 

 HMGCR

K248

2.50

3-hydroxy-3-methylglutaryl-coenzyme A reductase

 HNRNPA1

K350

12.44

Heterogeneous nuclear ribonucleoprotein A1

 HNRNPK

K198

2.54

Heterogeneous nuclear ribonucleoprotein K

 HSP90AA1

K443

6.15

Heat shock protein HSP 90-alpha

K362

19.99

 

 HSPA8

K71

2.91

Heat shock cognate 71 kDa protein

 IFNGR1

K285

4.02

Interferon gamma receptor 1

 ITGB1

K794

7.85

Integrin beta-1

 JAK1

K504

12.53

Tyrosine-protein kinase JAK1

K227

8.53

 

 LMNA

K270

11.70

Prelamin-A/C

 LMNB1

K389

4.70

Lamin-B1

K102

6.05

 

 LSS

K432

1.97

Lanosterol synthase

 MAGED1

K656

4.57

Melanoma-associated antigen D1

 MCL1

K40

2.22

Induced myeloid leukemia cell differentiation protein Mcl-1

 MMP15

K662

9.19

Matrix metalloproteinase-15

 MTA2

K611

4.24

Metastasis-associated protein MTA2

 MYH10

K689

2.02

Myosin-10

 MYRF

K749

3.47

Myelin regulatory factor

 NCKAP1

K12

6.03

Nck-associated protein 1

 NDFIP2

K193

2.11

NEDD4 family-interacting protein 2

 NEDD4

K874

17.30

E3 ubiquitin-protein ligase NEDD4

 NME2

K12

7.44

Nucleoside diphosphate kinase B

K100

1.69

 

 NONO

K198

2.76

Non-POU domain-containing octamer-binding protein

 OTUB1

K84

1.42

Ubiquitin thioesterase OTUB1

 PABPC4

K188

3.04

Polyadenylate-binding protein 4

 PI4K2A

K240

5.04

Phosphatidylinositol 4-kinase type 2-alpha

 PKM

K270

1.89

Pyruvate kinase PKM

 PLCXD1

K227

2.31

PI-PLC X domain-containing protein 1

 PPP2R1B

K200

6.95

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

 PRKAR1A

K261

3.80

cAMP-dependent protein kinase type I-alpha regulatory subunit

 PSMA7

K115

3.09

Proteasome subunit alpha type-7

 PSMB3

K77

7.85

Proteasome subunit beta type-3

 PSMC3

K245

6.84

26S proteasome regulatory subunit 6A

 PSMC5

K94

1.37

26S proteasome regulatory subunit 8

 PSMD2

K66

2.17

26S proteasome non-ATPase regulatory subunit 2

 PTBP1

K508

4.84

Polypyrimidine tract-binding protein 1

 RAB5C

K117

17.55

Ras-related protein Rab-5C

 RACGAP1

K292

1.95

Rac GTPase-activating protein 1

 RACK1

K106

3.77

Receptor of activated protein C kinase 1

 RAD18

K218

2.00

E3 ubiquitin-protein ligase RAD18

 RDX

K79

2.07

Radixin

 RNF114

K126

4.31

E3 ubiquitin-protein ligase RNF114

 RNF167

K272

1.61

E3 ubiquitin-protein ligase RNF167

 RPL12

K61

4.28

60S ribosomal protein L12

 RPL24

K93

2.45

60S ribosomal protein L24

K27

3.73

 

 RPL3

K286

3.50

60S ribosomal protein L3

 RPL30

K26

5.15

60S ribosomal protein L30

 RPL31

K70

4.31

60S ribosomal protein L31

 RPL6

K262

2.49

60S ribosomal protein L6

 RPL7A

K48

2.17

60S ribosomal protein L7a

K245

4.07

 

 RPS17

K19

11.59

40S ribosomal protein S17

 RPS27A

K6

2.12

Ubiquitin-40S ribosomal protein S27a

 RPS3

K141

2.02

40S ribosomal protein S3

 RPSA

K89

5.62

40S ribosomal protein SA

 RRM1

K376

2.47

Ribonucleoside-diphosphate reductase large subunit

 SCD

K341

6.02

Stearoyl-CoA desaturase

 SCP2

K438

9.43

Sterol carrier protein 2

 SFPQ

K421

2.20

Splicing factor, proline- and glutamine-rich

 SGTA

K200

8.44

Small glutamine-rich tetratricopeptide repeat-containing protein alpha

K160

9.16

 

 SLC20A1

K389

1.78

Sodium-dependent phosphate transporter 1

 SMARCA5

K929

6.41

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

 SPART

K481

2.37

Spartin

 SPTLC1

K197

4.47

Serine palmitoyltransferase 1

 SUV39H1

K138

5.91

Histone-lysine n-methyltransferase SUV39H1

 SYNCRIP

K363

17.81

Heterogeneous nuclear ribonucleoprotein Q

 TCAF1

K817

11.59

TRPM8 channel-associated factor 1

 TMUB1

K129

2.73

Transmembrane and ubiquitin-like domain-containing protein 1

K108

4.00

 

 TNFRSF1A

K242

7.92

Tumor necrosis factor receptor superfamily member 1A

 TPD52L2

K108

1.74

Tumor protein D54

 TPM1

K37

1.51

Tropomyosin alpha-1 chain

 TPR

K290

2.67

Nucleoprotein TPR

 UBE2L3

K73

2.11

Ubiquitin-conjugating enzyme E2 L3

 UBE2N

K82

8.56

Ubiquitin-conjugating enzyme E2 N

 UBE2O

K132

5.16

(E3-independent) E2 ubiquitin-conjugating enzyme

 UBE2T

K91

2.10

Ubiquitin-conjugating enzyme E2 T

K48

2.74

 

 UBE3A

K330

1.88

Ubiquitin-protein ligase E3A

 UBTD2

K68

2.88

Ubiquitin domain-containing protein 2

 UCK2

K78

7.42

Uridine-cytidine kinase 2

 USP14

K441

8.10

Ubiquitin carboxyl-terminal hydrolase 14

 USP25

K444

5.44

Ubiquitin carboxyl-terminal hydrolase 25

K201

2.12

 

 USP5

K423

5.82

Ubiquitin carboxyl-terminal hydrolase 5

 VAMP3

K35

6.18

Vesicle-associated membrane protein 3

 VCP

K658

15.10

Transitional endoplasmic reticulum ATPase

K236

14.68

 

 VIM

K445

4.05

Vimentin

 WIZ

K1597

5.95

Protein Wiz

 YWHAZ

K49

3.87

14-3-3 protein zeta/delta

 ZFYVE16

K1257

46.92

Zinc finger FYVE domain-containing protein 16

Down-ubiquitination modification

 

 SLC4A7

K548

0.17

Sodium bicarbonate cotransporter 3

K31

0.39

 

 RNF114

K161

0.14

E3 ubiquitin-protein ligase RNF114

UBQLN1

K47

0.36

Ubiquilin-1

 TNFRSF10D

K241

0.29

Tumor necrosis factor receptor superfamily member 10D

 UBAP1

K177

0.56

Ubiquitin-associated protein 1

 FANCI

K523

0.39

Fanconi anemia group I protein

 ACBD3

K386

0.43

Golgi resident protein GCP60

 FAM234A

K15

0.61

Protein FAM234A

 RNF5

K93

0.36

E3 ubiquitin-protein ligase RNF5

 SLC29A1

K263

0.56

Equilibrative nucleoside transporter 1

K255

0.63

 

K249

0.54

 

 PKP4

K518

0.44

Plakophilin-4

 UIMC1

K31

0.19

BRCA1-A complex subunit RAP80

 DCUN1D1

K149

0.49

DCN1-like protein 1

 RNF185

K105

0.25

E3 ubiquitin-protein ligase RNF185

 STAM

K171

0.64

Signal transducing adapter molecule 1

 MICAL1

K1036

0.39

[F-actin]-monooxygenase MICAL1

 UBA3

K147

0.27

NEDD8-activating enzyme E1 catalytic subunit

 SLC43A3

K264

0.25

Equilibrative nucleobase transporter 1

K255

0.19

 

K249

0.31

 

 KTN1

K256

0.42

Kinectin

 H2AC25

K96

0.38

Histone H2A type 3

 SV2A

K143

0.45

Synaptic vesicle glycoprotein 2A

 TUBA1A

K60

0.24

Tubulin alpha-1A chain

 ZDHHC20

K96

0.24

Palmitoyltransferase ZDHHC20

 H2BC21

K109

0.56

Histone H2B type 2-E

 H2AC20

K119

0.57

Histone H2A type 2-C

 VAMP3

K42

0.38

Vesicle-associated membrane protein 3

 UBE2V2

K72

0.45

Ubiquitin-conjugating enzyme E2 variant 2

 SLC1A5

K10

0.46

Neutral amino acid transporter B(0)

 ABRAXAS2

K229

0.35

BRISC complex subunit Abraxas 2

 EIF3A

K420

0.36

Eukaryotic translation initiation factor 3 subunit A

 ADAM9

K781

0.51

Disintegrin and metalloproteinase domain-containing protein 9

 TRIM28

K750

0.04

Transcription intermediary factor 1-beta

 CALCOCO2

K339

0.25

Calcium-binding and coiled-coil domain-containing protein 2

 AHNAK

K4945

0.50

Neuroblast differentiation-associated protein AHNAK

 SLC20A2

K262

0.37

Sodium-dependent phosphate transporter 2

 GFPT1

K48

0.20

Glutamine–fructose-6-phosphate aminotransferase 1

 UBE3A

K323

0.55

Ubiquitin-protein ligase E3A

 UBXN1

K83

0.49

UBX domain-containing protein 1

 RPL19

K186

0.41

60S ribosomal protein L19

 BASP1

K38

0.33

Brain acid soluble protein 1

 PRKDC

K810

0.36

DNA-dependent protein kinase catalytic subunit

 UBE2L3

K96

0.40

Ubiquitin-conjugating enzyme E2 L3

K82

0.21

 

K138

0.67

 

K131

0.46

 

 YBX1

K137

0.69

Y-box-binding protein 1

 YWHAZ

K9

0.60

14-3-3 protein zeta/delta

 RPS27A

K27

0.75

Ubiquitin-40S ribosomal protein S27a

 HNRNPK

K422

0.10

Heterogeneous nuclear ribonucleoprotein K

 SUMO2

K33

0.42

Small ubiquitin-related modifier 2

 UBE2M

K92

0.68

NEDD8-conjugating enzyme Ubc12

 RPS20

K8

0.56

40S ribosomal protein S20

 VCP

K251

0.27

Transitional endoplasmic reticulum ATPase

K231

0.62

 

K109

0.56

 

 SLC12A2

K976

0.30

Solute carrier family 12 member 2

RAD23B

K51

0.46

UV excision repair protein RAD23 homolog B

 ATXN3

K200

0.72

Ataxin-3

 SLC16A1

K473

0.17

Monocarboxylate transporter 1

K224

0.41

 

 CAPZB

K267

0.25

F-actin-capping protein subunit beta

 NEDD4

K882

0.47

E3 ubiquitin-protein ligase NEDD4

 RPS10

K138

0.38

40S ribosomal protein S10

K139

0.50

 

 RPS9

K155

0.63

40S ribosomal protein S9

USP5

K360

0.72

Ubiquitin carboxyl-terminal hydrolase 5

 SLC1A4

K528

0.14

Neutral amino acid transporter A

K501

0.05

 

K493

0.14

 

K484

0.17

 

K3

0.29

 

 PEX19

K52

0.34

Peroxisomal biogenesis factor 19

 BSG

K366

0.22

Basigin

 RDX

K526

0.48

Radixin

 SLC6A6

K19

0.31

Sodium- and chloride-dependent taurine transporter

 GNA11

K107

0.44

Guanine nucleotide-binding protein subunit alpha-11

 MARCKS

K11

0.20

Myristoylated alanine-rich C-kinase substrate

 MSN

K165

0.28

Moesin

K162

0.31

 

K139

0.47

 

 ATP2B4

K735

0.34

Plasma membrane calcium-transporting ATPase 4

 CFL1

K144

0.48

Cofilin-1

 RPS3

K214

0.42

40S ribosomal protein S3

 PAM

K901

0.62

Peptidyl-glycine alpha-amidating monooxygenase

 TCP1

K541

0.43

T-complex protein 1 subunit alpha

 PRKCA

K316

0.54

Protein kinase C alpha type

 STMN1

K52

0.35

Stathmin

 H1-3

K65

0.45

Histone H1.3

K35

0.52

 

 H1-5

K49

0.71

Histone H1.5

K37

0.43

 

 H2AX

K128

0.45

Histone H2AX

 RPS2

K58

0.37

40S ribosomal protein S2

 CD46

K375

0.49

Membrane cofactor protein

 EZR

K139

0.65

Ezrin

 XRCC5

K195

0.07

X-ray repair cross-complementing protein 5

 PCNA

K164

0.52

Proliferating cell nuclear antigen

 HSPA8

K524

0.57

Heat shock cognate 71 kDa protein

 CNP

K261

0.22

2′,3′-cyclic-nucleotide 3′-phosphodiesterase

 VIM

K188

0.34

Vimentin

 SLC3A2

K147

0.52

4F2 cell-surface antigen heavy chain

 LDHB

K308

0.20

l-lactate dehydrogenase B chain

 RPN1

K538

0.42

Dolichyl-diphosphooligosaccharide–protein glycosyltransferase subunit 1

 HLA-A

K340

0.39

HLA class I histocompatibility antigen, A alpha chain

K364

0.09

 

K200

0.37

 

 LMNA

K97

0.26

Prelamin-A/C

K180

0.51

 

 NRAS

K128

0.31

GTPase NRas

 TDP2

K82

0.35

Tyrosyl-DNA phosphodiesterase 2

 MPZL1

K213

0.74

Myelin protein zero-like protein 1

 UBXN7

K84

0.03

UBX domain-containing protein 7

 SLC16A7

K463

0.23

Monocarboxylate transporter 2

 NUDT21

K29

0.55

Cleavage and polyadenylation specificity factor subunit 5

 EPB41L2

K374

0.58

Band 4.1-like protein 2

K144

0.17

 

K114

0.34

 

 SLC16A3

K448

0.49

Monocarboxylate transporter 4

K431

0.44

 

K428

0.39

 

 SLC16A4

K244

0.18

Monocarboxylate transporter 5

 SCAMP1

K89

0.55

Secretory carrier-associated membrane protein 1

 SCAMP3

K101

0.00

Secretory carrier-associated membrane protein 3

 EEF2K

K341

0.18

Eukaryotic elongation factor 2 kinase

 CLIC1

K119

0.31

Chloride intracellular channel protein 1

Back to article page

Journal of Translational Medicine

ISSN: 1479-5876

Contact us