Fig. 8

Correlation between LR score and clinical immune features. A. Bubble plot showing the correlation between the LR score and immune cell infiltration. The LR score was negatively correlated with most T-cell types. The LR score was positively correlated with the M2 macrophage fraction. B. Boxplot showing the comparison of immune cell ssGSEA scores with high/low LR score groups (TCGA-STAD). A high LR score was associated with lower CD8 + T-cell infiltration and higher macrophage infiltration. C. Boxplot showing the comparison of immune function ssGSEA scores with high/low LR score groups (TCGA-STAD). A low LR score had higher cell cytolytic activity and pro-inflammatory ability. D. Violin plot showing the comparison of TIDE scores between the high/low LR score groups. A high LR score has a higher TIDE score. High LR scores are more susceptible to immune evasion. E. Violin plot showing the comparison of TMB between the high/low LR score groups. Immunotherapy often yields more favorable outcomes for malignancies exhibiting elevated TMB. Low LR scores have higher TMB scores. F. Violin plot showing the comparison of LR scores between different TCGA subtypes. Patients with EBV and MSI may benefit from immunotherapy. GS and CIN are less likely to benefit from immunotherapy. CIN and GS had higher LR scores. Patients with EBV and MSI have lower LR scores. G. Violin plot showing the comparison of LR scores between different MSI subtypes. Patients with MSI-H have better immunotherapy sensitivity. MSI-H patients had lower LR scores. H. Violin plot showing the comparison of LR scores between different CIMP subtypes. CIMP-H and CIMP EBV had high methylation levels. High methylation levels are associated with greater immune cell infiltration. CIMP-H and CIMP-EBV had lower LR scores. I. Violin plot showing the comparison of LR scores between different TNM stages. Individuals with an advanced clinical stage exhibited an elevated LR score. J. The clinical heatmap shows the distribution of the LR score and various molecular subtypes in the TCGA cohort. K. Violin plot showing the comparison of LR scores between different ACRG subtypes. The prognosis for the MSI-H type is the most favorable, while the prognosis for the EMT type is the worst favorable. MSI-H exhibits the lowest LR score. The EMT type had the highest LR score. L. Violin plot showing the comparison of LR scores between different Lauren types. The diffuse type has the worst prognosis and is more prone to distant metastasis. Individuals diagnosed with diffuse gastric cancer exhibited the most elevated LR score. M. Clinical heatmap showing the distribution of the LR score and various molecular subtypes in the ACRG cohort. Wilcoxon test: *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001