Fig. 2

Inferring the cellular state of patient CD8 + T cells. A. UMAP diagram showing the 7 major CD8 + T-cell subsets B. Heatmap showing the expression of classic CD8 + T-cell function markers for different CD8 + T-cell subsets. CD8T-C4 was defined as an exhausted CD8 + T state. C. UMAP diagram showing each CD8 + T-cell subset major type-specific marker. D. Trajectory distribution diagram showing the position of each CD8 + T-cell subset in the differentiation process. The color changes from dark to light to simulate the start to end of the pseudotime process. E. Scale diagram showing T-cell types and CD8 + T-cell subset cellular composition in different disease states.