Fig. 1

Differential expression profiles between CD4⁺ PBLs and CD4⁺ TILs A Clustering analysis of mRNAs that are differentially expressed in CD4⁺ PBLs from healthy controls (HC), CD4⁺ PBLs from OC patients (OC-P), and CD4⁺ TILs from OC patients (OC-T). Each column represents a sample and each row represents a specific gene. Those labeled in red are upregulated genes, labeled in green are downregulated genes and labeled in black are non-significantly different genes. The color scale on the left is a comparison table of values and colors (log scale 10, from − 4 to + 4). B Significant enrichment top 10 pathways within signal transduction pathways in the three groups. C Expression of chemokine receptor-related differential genes in CD4⁺ T cells of HC-PBL (n = 10), OC-PBL (n = 10) and OC-TIL (n = 10) groups. D Expression levels of CCR8 on CD4⁺ T cells of HC-PBL (n = 22), OC-PBL (n = 27) and OC-TIL (n = 16) groups. Data are presented as means ± SD and analysed with Student’s t-test. (HC-PBL group: CD4⁺ PBLs from healthy controls; OC-PBL group: CD4⁺ PBLs from OC patients; OC-TIL group: CD4⁺ TILs from OC patients; **** P < 0.0001.)