Table 5 LncRNAs and miRNAs targeting for NPC therapeutic

miR-7

Upregulated by Curcumin

Triggered cell cycle arrest and apoptosis, retarded cell proliferation, migration and invasion by inhibiting Skp2

[196]

miR17-5p

Downregulation

Suppressed tumour proliferation via regulation of p21 protein

[197, 198]

miR-20a-5p

Downregulation

Enhance radiosensitivity via regulation of neuronal PAS domain protein 2 (NPAS2) gene

[199]

miR-26b

Upregulation

Enhance chemosensitivity (Cisplatin) by inhibiting JAG1 expression

[200]

miR29-c

Upregulated by knockdown of lncRNA X inactive-specific transcript (XIST) or HMG-box transcription factor 1 (HBP1)

Suppressed cell proliferation and enhance radiosensitive via reduce level of cyclin D1 and cyclin D3

[201, 202]

miR-93

Downregulation

Suppressed tumour growth and migration

[203]

miR-101

Upregulation

Suppressed metastasis and angiogenesis by negative regulation of integrin subunit alpha 3 (ITGA3) or Stathmin 1 (STMN1)

[190, 204]

miR-148b

Upregulation

Suppressed invasion, and metastasis by inhibiting metastasis-related gene 2 (MTA2)

[205]

miR-149

Downregulation

Suppressed proliferation, invasion and metastasis via the upregulation of plakophilin3 (PKP3) expression

[187]

miR-150

Upregulation

Suppressed cell proliferation and G1/S transition by targeting CCND1, CCND2, CDK2 and CCNE2

[206]

miR-185-3p

Upregulation

Enhance radiosensitivity through inhibition of mothers against decapentaplegic homolog 7 (SMAD7)

[207]

miR-205

Downregulation

Suppressed tumour growth and migration

[203]

miR-212

Upregulation

Suppressed invasion and migration by targeting SRY-Box Transcription Factor 4 (SOX4)

[208]

miR-324-3p

Upregulation

Suppressed invasion, cell proliferation, apoptosis by negative regulation of GLI Family Zinc Finger 3 (GLI3) gene

[209]

miR-422a

Upregulation

Suppressed EMT and metastasis by targeting FOXQ1

[186]

miR-432

Upregulation

Suppressed invasion and migration by regulation E2F transcription factor 3 (E2F3) expression

[210]

miR-504

Downregulation

Enhance radiosensitivity via upregulation of NRF1

[185]

LncRN UCA1

Downregulation

Suppressed invasion and cell proliferation via miR-145/A disintegrin and metalloprotease 17 (ADAM17) axis

[188]

LncRN CASC9

Downregulation

Suppressed the cancer progression by destabilising the HIF1α

[189]

LncRN AFAP1-AS1

Downregulation

Prevent to be co-expressed with PD-1 to promote immune escape

[211]

LncRN MEG3

Upregulation

Induced cell cycle arrest, inhibited cell proliferation and colony formation

[192]

LncRN PVT1

Downregulation

Enhance radiosensitivity via regulation of DNA damage repair pathway

[191]

LncRN ANCR

Downregulation

Enhance radiosensitivity via regulation of PTEN expression

[183]

LncRN MALAT1

Downregulation

Enhance radiosensitivity via regulation of miR-1/slug axis

[184]

LncRN NEAT1

Downregulation

Suppressed tumourigenesis and enhance chmeosensitivity (cisplatin) via regulation of miR-124 and Rsf-1/Ras-MAPK/let-7a-5p axis

[182]

LncRNA LINC00460

Downregulation

Suppressed EMT via regulation of miR-30a-3p/Ras-related protein 1A (Rap1A) axis

[212]

LncRNA NKILA

Upregulation

Suppressed carcinogenesis through the inhibition of NF-κB signalling

[213]

LncRNA FAM225A

Downregulation

Suppressed cell proliferation and invasion by regulation of ITGB3 and FAK/PI3K/Akt pathways

[194]

LncRNA DRAIC

Downregulation

Suppressed invasion and migration by miR-122/SATB1 axis

[214]

LncRNA TP73-AS1

Downregulation

Suppressed migration and invasion via regulation of miR-495/JAM-A axis

[215]

LncRNA FOXD3-AS1

Downregulation

Suppressed colony formation, invasion and migration via regulation of miR-185-3p/FOXD3 axis

[195]