Table 3 Genome-wide association analysis of pancreatic cancer-related metabolites

HMDB0244373

Eicosa-11,14,17-trienoic acid

rs6731366

chr2:132891267 (GRCh38.p14)

A

NCKAP5

1.740 [0.833–3.633]

rs11860247

chr16:16071432 (GRCh38.p14)

A

ABCC1

1.016 [0.534–1.934]

rs201237448

chr3:157725970 (GRCh38.p14)

A

0.869 [0.388–1.944]

rs4541064

chr16:85230276 (GRCh38.p14)

C

GSE1

1.037 [0.615–1.748]

rs114089627

chr3:3658708 (GRCh38.p14)

A

1.106 [0.503–2.432]

rs138810234

chr4:161529556 (GRCh38.p14)

C

FSTL5

1.430 [0.834–2.450]

rs77806269

chr3:12881670 (GRCh38.p14)

T

LINC02022, LOC105376956

0.749 [0.363–1.548]

rs2370981

chr14:79402892 (GRCh38.p14)

G

NRXN3

0.371 [0.142–0.968]

rs117753991

chr16:77579192 (GRCh38.p14)

G

0.951 [0.518–1.748]

rs201592606

chr4:139691697 (GRCh38.p14)

G

MGST2

1.089 [0.683–1.738]

HMDB0000715

Kynurenic acid

rs73448444

chr13:28731007 (GRCh38.p14)

G

1.075 [0.614–1.883]

rs200475458

chr17:16403690–703 (GRCh38.p14)

C

0.833 [0.463–1.498]

rs187490

chr5:35045022 (GRCh38.p14)

G

AGXT2

1.256 [0.787–2.005]

rs604140

chr2:67422625 (GRCh38.p14)

C

1.734 [0.834–3.602]

rs78053646

chr12:231126 (GRCh38.p14)

T

SLC6A13, PARM1

1.233 [0.746–2.039]

rs890289

chr4:75,047,822 (GRCh38.p14)

A

LOC107986289

0.998 [0.481–2.070]

rs9908634

chr17:79431371 (GRCh38.p14)

T

RBFOX3

1.224 [0.603–2.485]

rs12909308

chr15:61777037 (GRCh38.p14)

T

1.223 [0.770–1.942]

rs10407389

chr19:36484416 (GRCh38.p14)

G

ZNF566

0.996 [0.559–1.775]

rs72747726

chr15:69,899,377 (GRCh38.p14)

G

1.093 [0.680–1.757]

HMDB0011741

γ-Glutamyl tyrosine

rs59519100

chr20:33868761 (GRCh38.p14)

T

1.701 [1.046–2.765]

rs193488

chr5:136703440 (GRCh38.p14)

G

1.920 [0.948–3.890]

rs202074299

chr13:90,574,203 (GRCh38.p14)

T

1.126 [0.689–1.839]

HMDB0002038

N(6)-Methyllysine

rs200559669

chr6:123584482 (GRCh38.p14)

C

TRDN

0.685 [0.415–1.131]

rs918171

chr19:3336541 (GRCh38.p14)

C

0.947 [0.599–1.499]

rs2374205

chr4:113984965 (GRCh38.p14)

G

LOC124900762

0.893 [0.523–1.524]

rs116931887

chr6:143808387 (GRCh38.p14)

C

PHACTR2

0.971 [0.612–1.241]

HMDB0011130

LysoPE(18:0/0:0)

rs11083238

chr18:27943526 (GRCh38.p14)

T

CDH2

1.299 [0.744–2.267]

rs6731366

chr2:132891267 (GRCh38.p14)

A

NCKAP5

1.329 [0.615–2.874]

rs12059514

chr1:102370790 (GRCh38.p14)

C

0.987 [0.571–1.706]

rs28565987

chr15:88048299 (GRCh38.p14)

A

NTRK3

0.829 [0.432–1.590]

rs2505110

chr10:30181971 (GRCh38.p14)

G

0.843 [0.514–1.384]

rs62525721

chr8:129066916 (GRCh38.p14)

T

0.986 [0.430–2.259]

rs8052560

chr16:88710834 (GRCh38.p14)

C

CTU2

1.391 [0.734–2.636]

rs117723718

chr4:40487925 (GRCh38.p14)

G

RBM47

1.050 [0.489–2.254]

rs28705703

chr6:167502412 (GRCh38.p14)

G

1.650 [0.823–3.306]

rs9829051

chr3:31491669 (GRCh38.p14)

G

1.149 [0.628–2.102]

rs375927045

chr7:16220625 (GRCh38.p14)

C

CRPPA

0.624 [0.370–1.052]

rs881433

chr18:44864508 (GRCh38.p14)

A

SETBP1

1.293 [0.799–2.092]

rs11164375

chr1:102083600 (GRCh38.p14)

T

2.194 [1.095–4.394]

rs117753153

chr3:24689035 (GRCh38.p14)

G

1.041 [0.446–2.427]

rs1923773

chr13:53176219 (GRCh38.p14)

G

0.999 [0.576–1.732]

rs141483946

chr11:13570434 (GRCh38.p14)

A

1.472 [0.751–2.884]

rs9345335

chr6:93188629 (GRCh38.p14)

G

0.999 [0.605–1.651]

rs78505433

chr15:49737092 (GRCh38.p14)

T

1.642 [0.761–3.547]

rs57966757

chr18:5919654 (GRCh38.p14)

A

LOC121725015

0.938 [0.477–1.844]

rs4727289

chr7:93397016 (GRCh38.p14)

G

0.743 [0.407–1.356]

rs55721115

chr14:34277292 (GRCh38.p14)

G

0.515 [0.212–1.250]

HMDB0304504

Trans-3′-hydroxy cotinine

rs74600139

chr5:44446171 (GRCh38.p14)

C

0.845 [0.531–1.344]

rs8100204

chr19:19282905 (GRCh38.p14)

A

SUGP1

0.763 [0.472–1.234]

rs148195640

chr20:59240551 (GRCh38.p14)

T

ZNF831

0.754 [0.435–1.306]

rs4308248

chr3:134302128 (GRCh38.p14)

G

0.729 [0.327–1.621]

HMDB0012273

Palmitic amide

rs13043798

chr20:23283897 (GRCh38.p14)

A

0.709 [0.446–1.127]

rs13132855

chr4:44399250 (GRCh38.p14)

A

KCTD8

1.038 [0.551–1.954]

rs7949816

chr11:60278427 (GRCh38.p14)

A

0.778 [0.453–1.338]

rs2724067

chr7:93831676 (GRCh38.p14)

A

0.877 [0.552–1.393]

rs149210546

chr4:8824426 (GRCh38.p14)

C

1.458 [0.896–2.375]

rs76582834

chr4:164383443 (GRCh38.p14)

C

MARCHF1

0.568 [0.280–1.152]

HMDB0000687

l-Leucine

rs76417681

chr2:61231241 (GRCh38.p14)

C

USP34

0.610 [0.271–1.371]

rs17684350

chr10:18374682 (GRCh38.p14)

C

CACNB2

1.597 [0.814–3.133]

rs55828915

chr1:207785790 (GRCh38.p14)

T

CD46

0.742 [0.335–1.642]

rs57192942

chr10:127846701 (GRCh38.p14)

T

1.415 [0.863–2.320]

rs72709073

chr9:69206346 (GRCh38.p14)

C

TJP2

0.749 [0.331–1.696]

rs7182182

chr15:54,330,440 (GRCh38.p14)

A

UNC13C

0.848 [0.395–1.822]

rs11525305

chr10:6632812 (GRCh38.p14)

A

LINC02648

1.365 [0.688–2.708]

rs74724211

chr19:44209431 (GRCh38.p14)

G

ZNF227

0.847 [0.447–1.605]

rs79500165

chr2:141763014 (GRCh38.p14)

T

LRP1B, LOC107985779

0.663 [0.271–1.626]

rs72805402

chr10:75306714 (GRCh38.p14)

A

ZNF503

2.150 [1.258–3.674]

rs687168

chr17:14441416 (GRCh38.p14)

C

1.281 [0.657–2.495]

rs13388819

chr2:64599202 (GRCh38.p14)

T

LOC105374773

1.278 [0.681–2.398]

rs77464636

chr7:2301325 (GRCh38.p14)

A

SNX8

0.85 [0.459–1.574]

rs7525555

chr1:202170575 (GRCh38.p14)

G

PTPRVP

0.747 [0.420–1.329]

rs7175639

chr15:50210373 (GRCh38.p14)

C

SLC27A2

1.005 [0.609–1.660]

rs117920703

chr9:34250372 (GRCh38.p14)

A

UBAP1

0.449 [0.185–1.093]

rs28438600

chr8:15523840 (GRCh38.p14)

A

0.598 [0.252–1.418]

rs17134252

chr11:99717399 (GRCh38.p14)

A

CNTN5

0.978 [0.448–2.133]

rs55870181

chr14:84615718 (GRCh38.p14)

T

1.821 [1.123–2.951]

rs147699000

chr22:44353381 (GRCh38.p14)

A

0.901 [0.428–1.899]

rs8074518

chr17:14443114 (GRCh38.p14)

G

0.970 [0.526–1.792]

rs73497629

chr9:100688200 (GRCh38.p14)

C

1.258 [0.768–2.060]

rs12429312

chr13:22915866 (GRCh38.p14)

A

LINC00621

0.908 [0.539–1.530]

rs149903005

chr13:66587358–64 (GRCh38.p14)

C

PCDH9, LOC105370247

1.133 [0.639–2.011]

HMDB0000448

Adipic acid

rs6057003

chr20:9908557 (GRCh38.p14)

C

0.853 [0.520–1.400]

rs10846689

chr12:124601819 (GRCh38.p14)

T

1.056 [0.610–1.826]

rs73608605

chr8:39240193 (GRCh38.p14)

G

ADAM32

1.357 [0.730–2.521]

rs12361624

chr11:30658520 (GRCh38.p14)

G

1.422 [0.859–2.354]

rs837465

chr12:124534405 (GRCh38.p14)

A

NCOR2

0.943 [0.539–1.647]

rs6964529

chr7:54293427 (GRCh38.p14)

C

1.064 [0.567–1.993]

rs6739384

chr2:56142078 (GRCh38.p14)

A

LOC105374690

0.527 [0.248–1.124]

rs9291437

chr4:22163632 (GRCh38.p14)

C

1.163 [0.710–1.907]

HMDB0013205

9-Decenoylcarnitine

rs117445640

chr4:179766591 (GRCh38.p14)

T

0.963 [0.556–1.669]

rs17116178

chr11:113956604 (GRCh38.p14)

T

0.787 [0.442–1.399]

rs2836817

chr21:39001801 (GRCh38.p14)

C

LINC02940

0.639 [0.390–1.049]

rs71364155

chr17:12218522 (GRCh38.p14)

T

1.101 [0.688–1.762]

rs1532216

chr12:99210187 (GRCh38.p14)

A

ANKS1B

1.186 [0.605–2.325]

HMDB0003759

5a-Pregnane-3,20-dione

rs74869776

chr12:30963077 (GRCh38.p14)

G

TSPAN11

0.716 [0.319–1.607]

rs79255083

chr4:66526962 (GRCh38.p14)

C

1.104 [0.561–2.173]

rs7760758

chr6:24036861 (GRCh38.p14)

A

0.636 [0.295–1.369]

rs9792660

chr9:29371008 (GRCh38.p14)

T

0.802 [0.497–1.295]