Fig. 1

Extramedullary lesions in patient 1 before and after chimeric antigen receptor (CAR) -T cells infusion. a The results of combined positron emission tomography and computed tomography (PET-CT) with 18F-fluorodeoxyglucose demonstrated increased glucose metabolic activity in the calvaria and tibia of patient 1 before CAR-T infusion (left and up right). The gross appearance of soft tissue masses in the calvaria (right middle) and tibia (bottom right) were shown. b No lesion was observed for patient 1 by physical examination and PET-CT at 3 months and 6 months after infusion