Table 1 The concentrations of 13 key targets essential for immune response in 2D-4-culture and 3D-4-culture

23.88 ± 3.83

37.92 ± 3.01

1.25 ± 0.26

0.81 ± 0.06

17.20 ± 2.50

12.56 ± 1.67

1.52 ± 2.50

1.80 ± 0.20

1.25 ± 0.15

2.29 ± 0.56

6.89 ± 0.65

8.89 ± 0.38

25.02 ± 2.00

27.53 ± 2.40

10.00 ± 1.30

18.53 ± 2.30

7.41 ± 0.89

9.48 ± 0.54

1818.83 ± 195.96

5635.37 ± 471.29

4501.92 ± 258.42

11,507.70 ± 610.52

5821.76 ± 693.03

12,041.87 ± 735.85

3986.01 ± 208.70

4501.92 ± 258.42