Fig. 3

Differences of drug resistance in 2D-4-culture and 3D-4-culture. Cell viability of cells in 2D-4-culture and 3D-4-culture treated with cisplatin by different concentrations for 24 h (A), 48 h (B), and 72 h (C). D Representative bright field microscopy images of cells in 3D-4-culture treated with cisplatin by different concentrations for 24 h,48 h, and 72 h. Statistical significance, **P < 0.01, ***P < 0.001