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Table 2 Cox proportional hazard ratios (HRs) of the identified cMetS-S trajectory patterns for incidence T2DM in total and according to sex

From: Trajectory patterns of metabolic syndrome severity score and risk of type 2 diabetes

 

Events

IR (95% CI)*

HR (95% CI)

Test PH p-valueb

Model 1

Model 2

Model 3

Model 4

Men (n = 1648)

       

Class 1 (n = 202)

4

2.3 (0.9–6.1)

1.0 (Reference)

1.0 (Reference)

1.0 (Reference)

1.0 (Reference)

Class 2 (n = 813)

68

9.5 (7.5–12.0)

3.70 (1.35–10.18)

3.70(1.35–10.18)

3.36(1.22–9.25)

2.83(1.03–7.81)

0.6

Class 3 (n = 633)

129

24.6 (20.7–29.3)

10.22 (3.77–27.68)

10.20(3.77–27.63)

8.90(3.27–24.25)

6.80(2.48–18.58)

0.98

Women (n = 2283)

       

Class 1 (n = 729)

19

2.9 (1.9–4.6)

1.0 (Reference)

1.0 (Reference)

1.0 (Reference)

1.0 (Reference)

Class 2 (n = 1052)

100

10.6 (8.7–12.9)

3.31 (2.00–5.45)

3.33(2.02–5.49)

3.10(1.86–5.11)

2.52(1.51–4.18)

0.07

Class 3 (n = 502)

152

37.9 (32.3–44.4)

11.95 (7.20–19.85)

12.11(7.29–20.12)

10.63(6.33–17.86)

7.65(4.54–12.89)

0.13

Total (n = 3931)

       

Class 1 (n = 931)

23

2.8 (1.8–4.2)

1.0 (Reference)

1.0 (Reference)

1.0 (Reference)

1.0 (Reference)

Class 2 (n = 1865)

168

10.1 (8.7–11.8)

3.13 (2.01–4.87)

3.10(1.99–4.84)

2.87(1.84–4.48)

2.44(1.56–3.81)

0.08

Class 3 (n = 1135)

281

30.4 (27.0–34.2)

9.58 (6.17–14.87)

9.47(6.10–14.71)

8.37(5.35–13.09)

6.38(4.07–10.01)

0.25

  1. Model 1: Adjusted for age and sex
  2. Model 2: Adjusted for age, sex, education, DM family history
  3. Model 3: Adjusted for age, sex, education, DM family history, physical activity, obesity, antihypertensive drug use, lipid-lowering drug use
  4. Model 4: Adjusted for age, sex, education, DM family history, physical activity, obesity, antihypertensive drug use, lipid-lowering drug use. and fasting plasma glucose
  5. The population was classified into three trajectory classes using latent class analysis, including trajectories of low (class 1), medium (class 2), and high (class 3) cMetS-S
  6. cMetS-S continuous metabolic syndrome severity score;
  7. aIR Incidence rate per 1,000 person-years
  8. bThe proportional hazards assumption was tested based on Schoenfeld residuals.There is no evidence that proportional-hazards assumption has been violated. In the fully adjusted model (model 4), the p-value of the global test proportional hazards assumption is equal to 0.37