Fig. 5
From: CRISPR/Cas9 technology: applications in oocytes and early embryos
Diagram summarizing the experimental steps of editing POU5F1 (OCT4) locus in mouse zygote (green) and human zygote (blue) using the CRISPR-Cas9 strategy. Different effects on human embryo development were compared in the presence and absence of the OCT4 gene. The role of OCT4 was also compared between mouse and human embryo development