Fig. 7

THBS1-CXCL9/CXCL10 axis promotes the recruitment of CD8⁺ T cells. A The migration of CD8⁺ T cells coincubated with supernatant from hctrl and hTHBS1 cells, and supernatant handling with CXCL9 or CXCL10 neutralizing antibody. B The migration of CD8⁺ T cells coincubated with supernatant from siTHBS1 or sictrl cells. hctrl and hTHBS1 cells were inoculated subcutaneously (n = 6 mice per group). CXCL9/CXCL10 neutralizing antibody or PBS was administrated according to (C). The tumor sizes, growth curves and weights of the three groups were shown as (D–F), respectively. G Analysis of the population of TILs by flow cytometry. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001