Fig. 8

MSI-1436 induces hyperphosphorylation of AMPK, JAK2 and STAT 3 in primary human macrophages exposed to acute oxLDL-C challenge. A Western blots from stimulation experiments in primary human macrophages exposed to acute oxLDL-C stimulus in the presence or absence of MSI-1436 over a 3h time course. B-D Western blot quantifications of pAMPK, pSTAT3 and pJAK2. Quantification was performed using Image J software. Data are represented as mean ± S.E.M. and were analyzed by bootstrapped ANOVA followed by Bonferonni-corrected multiple bootstrapped t tests in case of a significant omnibus test