Fig. 7

MSI-1436 treatment results in increased expression of LXRa/ABCA1 expression in foam cells. A Western blots from stimulation experiments in Thp1 derived macrophages with varying concentrations of MSI-1436 over a 3h time course. B–D Western blot quantifications of ABCA1, LXRa and PTP1B in Thp1-derived foam cells. E–G Western blot quantifications of ABCA1, LXRa and PTP1B in non-lipid laden Thp-1 derived macrophages. Quantification was performed using Image J software. Data are represented as mean ± S.E.M. and were analyzed by bootstrapped ANOVA followed by Bonferonni-corrected multiple bootstrapped t tests in case of a significant omnibus test