Fig. 6

MSI-1436 induces hyperphosphorylation of AMPK and JAK2 in Thp1 derived macrophages. A Western blots from stimulation experiments in Thp1 derived macrophages with varying concentrations of MSI-1436 over a 3h time course. B–G Western blot quantifications of pAMPK, AMPK, pSTAT3, STAT3, pJAK2 and JAK2 in Thp1-derived non-lipid laden macrophages. Quantification was performed using Image J software. Data are represented as mean ± S.E.M. and were analyzed by bootstrapped ANOVA followed by Bonferonni-corrected multiple bootstrapped t tests in case of a significant omnibus test