Increased co-expression of PD1 and TIM3 is associated with poor prognosis and immune microenvironment heterogeneity in gallbladder cancer

Table 1 The correlation between PD1, TIM3 and PD1/TIM3 expression status and clinicopathological characteristics in GBC

Characteristic		PD1 expression			TIM3 expression			PD1/TIM3 co-high expression
Characteristic	Cases.n	High	Low	P value	High	Low	P value	Present	Absent	P value
Gender				0.706			0.954			0.689
Female	61	39	22		32	29		29	32
Male	66	39	27		36	30		28	38
Age				0.913			0.934			0.452
< 60 years	50	31	19		27	23		25	25
> 60 years	77	47	30		41	36		32	45
Tumor size				0.813			0.824			0.878
> 3 cm	67	40	27		37	30		31	36
< 3 cm	60	38	22		31	29		26	34
Microvascular invasion				0.835			0.955			0.953
no	75	45	30		40	35		33	42
yes	52	33	19		28	24		24	28
T				0.029			0.962			0.243
Low(1.2)	46	22	24		24	22		17	29
High(3.4)	81	56	25		44	37		40	41
N				0.002			0.053			0.013
Low(0)	52	23	29		22	30		16	36
High(1.2)	75	55	20		46	29		41	34
M				0.030			0.893			0.274
Absent(0)	94	52	42		50	44		39	55
Present(1)	33	26	7		18	15		18	15
TNM stage				0.014			0.270			0.075
Low(I.II.III)	59	29	30		28	31		21	38
High(IV)	68	49	19		40	28		36	32
Histologic differentiation				0.039			0.186			0.061
Moderate. Well	75	40	35		36	39		28	47
Poor	52	38	14		32	20		29	23
CA19-9				0.539			0.882			0.791
Negative	54	31	23		28	26		23	31
Positive	73	47	26		40	33		34	39
CEA				0.275			0.880			0.627
Negative	82	47	35		43	39		35	47
Positive	45	31	14		25	20		22	23

ISSN: 1479-5876