Fig. 5

Distinct immune microenvironments in primary tumor and liver metastasis. A, Representative mIHC images of immune checkpoints (PD1, TIM3, TIGIT, LAG3) and Immune cell marker (CD8, CD4, CD68, Foxp3) staining within the primary tumor and its paired liver metastases (Red scale bar is 100 μm). B, Comparison of immune checkpoints H-score between primary tumor and liver metastasis in GBC (***P < 0.001). C, The correlation between the H-score of immune checkpoints in the primary tumor and that in the liver metastasis