Table 2 List of A37 modules undergoing prioritization
From: Harnessing large language models (LLMs) for candidate gene prioritization and selection
Module ID | N Genes | Gene Symbols | Status | Top pick | Report |
|---|---|---|---|---|---|
M9.2 | 30 | ALAS2, BCL2L1, BPGM, C14ORF45, C1ORF128, CA1, EPB42, FAM46C, FECH, GMPR, GPR146, GYPB, GYPE, IFIT1L, KRT1, MARCH8, NFIX, OR2W3, OSBP2, PLEK2, SELENBP1, SLC14A1, SLC4A1, SNCA, TMCC2, TMOD1, TNS1, TRIM10, TUBB2A, XK | Completed | ALAS2 | Additional File 2 |
M11.2 | 39 | ABCC4, AMFR, BAT3, BMP2K, C17ORF39, C9ORF40, DNAJB2, EIF1B, GDE1, GNA12, HS.211743, HS.57079, IQWD1, JAZF1, MED25, NSUN3, ODC1, POLR1D, PPP2R5B, PSME4, RANBP10, RNF14, RSRC1, SELK, SLC2A1, SNX3, TBC1D22B, TMEM183A, TMEM183B, UBE2F, UBQLN1, WBP2, WDR26, WDR45, WDR51B, WNK1, ZBTB44, ZER1, ZNF653 | Completed | WNK1 | Additional File 3 |
M11.3 | 24 | ASCC2, C18ORF10, C18ORF10, DPM2, EPB49, FBXO7, FBXO7, GATA1, HAGH, HEMGN, HEMGN, HMBS, KEL, LOC284422, LOC440359, LOC441081, MBNL3, MBNL3, MYL4, PDZK1IP1, PHOSPHO1, RUNDC3A, SESN3, TESC, TGM2, TRIM10, TSPAN5, VWCE | Completed | HMBS | Additional File 4 |
M11.4 | 25 | AP2M1, AP2M1, AP2S1, ATG9A, ATG9A, B4GALT3, BCL2L13, C13ORF15, C19ORF62, CYB5R3, DAP, DENND1A, FAM134A, HK1, JUND, MSI2, NTAN1, NUCB1, PA2G4, POLR1D, TCEB2, UBAC1, UBAP1, UBL7, UROD, WDR13, WIPI2, ZMAT2 | Completed | MSI2 | Additional File 5 |
M12.11 | 24 | ALDH5A1, BNIP3L, BNIP3L, C20ORF108, DNAJA4, FAM104A, HBD, HS.105618, HS.291319, ISCA1L, LOC389293, MPP1, MXI1, PRDX2, PRDX2, RAB2B, RAD23A, RIOK3, RPIA, SIAH2, SLC1A5, TFDP1, TFDP1, TRAK2, TSTA3, UBE2O, YOD1 | Completed | HBD | Additional File 6 |
M13.26 | 40 | AP2A1, ATP6V0C, BMP2K, C16ORF35, C19ORF22, C2ORF24, C9ORF78, CCDC23, CREG1, EIF2AK1, ELOF1, FAM100A, FOXO4, FURIN, GABARAPL2, GCLC, GPX1, H1F0, HDGF, ISCA1, ISCA1, LYL1, MAF1, MKRN1, NINJ2, NP, PIM1, PINK1, PNPLA2, PRR6, PSMF1, RFESD, RNF123, RNF14, STK33, STOM, SYT15, TERF2IP, TFDP2, XPO7, YPEL3 | Completed | SLC2A1 | Additional File 7 |
M13.30 | 32 | ABCC13, ADIPOR1, ARL4A, BLVRB, BOAT, C16ORF35, CARM1, CES3, CSDA, FBXO9, FIS1, FKBP8, FLJ20489, GLUL, GSPT1, GUK1, GYPC, HAGH, HBM, HBQ1, HPS1, HPS1, PBX1, PTMS, SHARPIN, SLC25A39, ST6GALNAC4, ST6GALNAC4, TMEM86B, UBL7, UBXD1 | Completed | PBX1 | Additional File 8 |
M14.53 | 16 | BCL2L1, BSG, CDC34, CHPT1, CHPT1, FHL2, GLRX5, IGF2BP2, KLF1, LOC650832, LOC653778, LOC654103, MAP2K3, MARCH8, RBM38, RIOK3, TMEM63B | Completed | KLF1 | Additional File 9 |
M15.53 | 25 | BRD4, C16ORF35, CDKL1, DPM2, EPB41, HMBS, HPS1, IQWD1, KLC3, LOC643008, LOC648434, LOC650898, MAP2K3, MICAL2, MICALCL, MXI1, RAB3IL1, RP11-529I10.4, SLC38A5, SLC6A8, TCP11L2, TGM2, TMPRSS9, TTC25, WNK1 | Completed | BRD4 | Additional File 10 |
M15.74 | 21 | ANKRD9, ATP6V0C, C22ORF25, C5ORF4, E2F2, FHL2, HMG2L1, LGALS3, LOC653907, MAP2K3, MARCH2, MCOLN1, MGC13057, PPM1A, PPM1A, RNF10, RNF11, SLC6A10P, SMOX, SRRD, TMEM158, UBE2H | Completed | LGALS3 | Additional File 11 |
M15.100 | 17 | ARHGEF12, C14ORF45, CISD2, CMBL, FLCN, GCAT, GYPE, HBBP1, LOC253012, PCSK1N, PLVAP, RHD, SLC6A9, SPTB, TBCEL, TMEM56, YPEL4 | Completed | SPTB | Additional File 12 |