Fig. 6

Transcriptional profiles of the top 5 scoring candidate genes in reference leukocyte transcriptome datasets. The stacked bar graphs show levels of transcript abundance for top 5 scoring M9.2 genes, in: A a dataset comprising isolated leukocyte and hematopoietic progenitor populations contributed to the NCBI gene expression omnibus (GEO) by Novershtern et al. (GSE24759) and B a dataset comprising whole blood and leukocyte populations contributed by Speake et al. (GSE6042459). Abbreviated notations for the Novershtern dataset are as follows: HSC1, Hematopoietic stem cell CD133 + CD34dim; HSC2, Hematopoietic stem cell CD38- CD34 + ; CMP, Common myeloid progenitor; MEP, Megakaryocyte/erythroid progenitor; ERY1, Erythroid CD34 + CD71 + GlyA-; ERY2, Erythroid CD34- CD71 + GlyA-; ERY3, Erythroid CD34- CD71 + GlyA + ; ERY4, Erythroid CD34- CD71lo GlyA + ; ERY5, Erythroid CD34- CD71- GlyA + ; MEGA1, Colony Forming Unit-Megakaryocytic; MEGA2, Megakaryocyte; DENDa1, Plasmacytoid dendritic cell; DENDa2, Myeloid dendritic cell; GMP, Granulocyte/monocyte progenitor; GRAN1, Colony Forming Unit-Granulocyte; GRAN2, Granulocyte (Neutrophilic Metamyelocyte); GRAN3, Granulocyte (Neutrophil); MONO1, Colony Forming Unit-Monocyte; MONO2, Monocyte; BASO1, Basophil; EOS2, Eosinophil; Pre-BCELL2, Early B cell; Pre-BCELL3, Pro-B cell; BCELLa1, Naive B cell; BCELLa2, Mature B cell, able to class switch; BCELLa3, Mature B cell; BCELLa4, Mature B cell, class switched; NKa1, Mature NK cell_CD56- CD16 + CD3-; NKa2, Mature NK cell_CD56 + CD16 + CD3-; NKa3, Mature NK cell CD56- CD16- CD3-; NKa4, NKT cell; TCELL1, CD8 + effector memory RA; TCELL2, Naive CD8 + T cell; TCELL3, CD8 + effector memory cell; TCELL4, CD8 + central memory; TCELL6, Naive CD4 + T cell; TCELL7, CD4 + effector memory cell; TCELL8, CD4 + central memory; Note: NKa1-4 as well as DENDa1 and DENDa2 cells were isolated from adult peripheral blood, other cell populations were isolated from cord blood