Table 1 SNPs identified in targeted genes
Name/Gene ID | Description | Chromosomal location | SNPs | GnomAD/1000Genome | Ref Allele | Alt Allele | Location |
|---|---|---|---|---|---|---|---|
IL-10 | Interleukin 10 | 1:206,767,602–206,774,541 | rs1518111 rs1554286 rs3024509 | 0.29/0.42 0.26/0.40 0.04/0.02 | T A A | C G/T G | Intron variant Intron variant Intron variant |
IL-6 | Interleukin 6 | 7:22,766,819–22,771,617 | rs1800795 | 0.29/0.14 | C | G/T | Intron variant |
IL-1β | Interleukin 1 beta | 2:112,829,751–112,836,816 | rs1071676 rs1143627 rs1143633 rs1143634 rs1143639 | 0.19/0.13 0.44/0.47 0.30/0.31 0.19/0.13 0.19/0.13 | C G C G C | G A A/G/T A T | 3_Prime UTR variant Upstream variant Intron variant Exonic variant Intron variant |
TNF-α | Tumor Necrosis Factor-Alpha | 6:31,575,565–31,578,336 | rs3093662 rs3093664 rs3093665 | 0.07/0.07 0.07/0.07 0.02/0.02 | A A A | G G C | Intron variant Intron variant 3_Prime UTR variant |
CETP | Cholesteryl Ester Transfer Protein | 16:56,961,923–56,983,845 | rs708272 rs5030708 | 0.38/0.37 0.02/0.01 | G C | A/C T | Intron variant Intron variant |
HMGCR | 3-Hydroxy-3-Methylglutaryl-CoA Reductase | 5:75,336,329–75,364,001 | rs10474435 rs10515198 rs11742194 rs12916 rs142563098 rs3846662 rs3846663 rs5909 | 0.01/0.01 0.08/0.07 0.08/0.07 0.36/0.41 -/0.01 0.42/0.37 0.34/0.40 0.08/0.07 | T G C T T A C G | C A T A/C/G A/C G/T T A | 3_Prime UTR variant Intron variant Intron variant 3_Prime UTR variant Intron variant Intron variant Intron variant 3_Prime UTR variant |
TGFB1 | Transforming growth factor beta 1 | 19:41,330,323–41,353,922 | rs1800471 rs1800472 rs8179181 | 0.08/0.04 0.02/0.01 - / 0.07 | C G G | G/T A A/C/T | Exonic variant Intron variant Exonic variant |
CRP | C-Reactive Protein | 1:159,682,079–159,684,379 | rs1130864 rs1205 rs1417938 | 0.26/0.20 0.30/0.33 0.25/0.19 | G C T | A T A/C | Intron variant 3_Prime UTR variant Intron variant |
FADS | Fatty Acid Desaturase | 11:61,799,627–61,829,318 | rs7481842 | 0.13/0.09 | C | G/T | Intergenic variant |