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Table 3 Clinical characteristics of PREVEND participants with the FLI ≥ 60 according to AAA-1 status

From: Antibody against apolipoprotein-A1, non-alcoholic fatty liver disease and cardiovascular risk: a translational study

 

Overall (n = 112)

AAA-1 negative (n = 78)

AAA-1 positive (n = 34)

P-value

Demographic

 Age, yr

59 (50.5–69)

58.5 (50–70)

62 (52–67)

0.615

 Males, no. (%)

43 (38.3)

29 (37.1)

14 (41.7)

0.428

 Waist circumference, cm

107 (102–114)

106 (102–111)

107.7 (103–115.5)

0.188

 Weight, kg

93 (84–102)

92.2 (83–101)

95.7 (86.5–102)

0.272

 BMI, kg/m2

30.4 (28.8–32.9)

30.2 (28.7–32.4)

30.9 (28.8–33)

0.374

 Systolic blood pressure mm Hg

134 (123–146)

133 (122–146)

140.5 (127.5–149)

0.352

 Diastolic blood pressure mm Hg

76 (71–80)

76 (70–80)

75.5 (72–80)

0.752

 Current smoker, no. (%)

22 (19.6)

12 (15.3)

10 (29.4)

0.156

 Type 2 diabetes, no. (%)

16 (14.2)

10 (21.2)

6 (22)

0.577

 FRS (%) b

18.5 (11.7–30)

15.8 (11.1–28.8)

22.3 (15–30)

0.022

Biochemical

 Total-c mg/dl

189.8 (167.6–224.4)

189.8 (167.8–226.6)

190 (166.2–221.9)

0.912

 LDL-ca mg/dl

123.7 (100.2–155.8)

122 (100.2–158.4)

127 (98.4–155.8)

0.898

 HDL-c mg/dl

32.4 (26.9–37.1)

34 (27.4–39.4)

28.6 (23.9–35.5)

0.032

 TG mg/dl

162 (120.4–215.2)

161.6 (124.8–213)

170 (117.7–216.9)

0.755

 Plasma glucose, mg/dl

90 (84.6–106.2)

90 (84.6–107.1)

91.8 (84.6–106.2)

0.832

 ALP, U/l

47.5 (40–56.5)

45 (38–52)

52 (42–66)

0.008

 ALT, U/l

7.9 (5.6–10.1)

8 (6.1–10.1)

7.7 (5.6–11)

0.919

 AST, U/l

20 (16–26)

20 (16–24)

21.5 (14–27)

0.933

 GGT, U/l

36 (24–54.5)

34 (22–51)

37.5 (28–60)

0.375

 FLIc

82.3 (73.4–92.5)

81.4 (70.6–92.1)

87.6 (77.5–93.7)

0.072

  1. All continuous variables are expressed as median (interquartile range [IQR]) or number [no.] (percentages [%]). P-value (Mann–Whitney U-test for continuous variables and Fisher's exact test for categorical variables)
  2. total-c total cholesterol, LDL-c low density lipoprotein cholesterol, HDL-c high-density lipoprotein cholesterol, TG triglyceride, BMI body mass index, ALT alanine transaminase, AST aspartate transaminase, FLI fatty liver index, ALP alkaline phosphatase, GGT gamma-glutamyl-transferase, FRS Framingham risk score, AAA-1 anti-apolipoprotein A-1 IgG
  3. aLDL calculated according to Friedwald formula
  4. bFRS: calculated based on: sex, age, smoking status, presence of diabetes, hypertension treatment, total cholesterol, HDL cholesterol
  5. cFLI: (e 0.953*loge (triglycerides) + 0.139 * BMI + 0.718 * loge (ggt) + 0.053 * waist circumference − 15.745)/(1 + e 0.953 * loge (triglycerides) + 0.139 * BMI + 0.718 * loge (ggt) + 0.053 * waist circumference − 15.745) * 100