Fig. 3

AAA-1 directly contribute to the pro-inflammatory response in hepatocytes. Levels of IL-6 (a), IL-8 (b), TNF-α (c) and IL-10 (d) were assessed in cell supernatant after treating HepaRG cells with AAA-1 or control IgG for 24 h. Results are expressed as median with IQR and range of five independent experiments (N = 5). a *P = 0.015, **P = 0.008; b ^#P = 0.016, ^##P = 0.008; c ^§§P = 0.007 and d P = 0.095, by Mann–Whitney test