Table 8 Biochemical parameters (mean ± SD) at enrolling visit (week -4) and week 12 in VLCKD and HBD group
| Â | VLCKD | HBD | F, p-value |
|---|---|---|---|
WBC | |||
 Week -4 | 6.50 ± 1.43 | 6.08 ± 1.69 | F = 2.042, 0.161 |
 Week 12 | 5.74 ± 1.02 | 6.08 ± 1.44 | |
 Δ | − 0.76 ± 1.50* p < 0.05 | 0.00 ± 1.82 | |
Hematocrit | |||
 Week -4 | 42.91 ± 9.26 | 41.14 ± 3.67 | F = 0.069, P = 0.794 |
 Week 12 | 40.81 ± 2.28 | 39.75 ± 4.41 | |
 Δ | − 2.09 ± 10.01 | − 1.39 ± 3.09 | |
PLT | |||
 Week -4 | 268.96 ± 62.51 | 244.73 ± 61.21 | F = 1.796, p = 0.188 |
 Week 12 | 245.28 ± 67.49 | 245.93 ± 83.25 | |
 Δ | − 23.68 ± 54.96* p < 0.05 | 1.20 ± 59.95 | |
Neutrophils | |||
 Week -4 | 3.84 ± 1.04 | 3.58 ± 1.25 | F = 1.414, p = 0.242 |
 Week 12 | 3.33 ± 0.86 | 3.52 ± 1.14 | |
 Δ | − 0.51 ± 0.94* p < 0.05 | − 0.06 ± 1.45 | |
Lymphocytes | |||
 Week -4 | 2.07 ± 0.41 | 2.00 ± 0.52 | F = 0.235, p = 0.631 |
 Week 12 | 2.07 ± 0.43 | 2.07 ± 0.50 | |
 Δ | 0.002 ± 0.42 | 0.07 ± 0.41 | |
Monocytes | |||
 Week -4 | 0.38 ± 0.13 | 0.33 ± 0.12 | F = 1.490,p = 0.230 |
 Week 12 | 0.30 ± 0.09 | 0.33 ± 0.15 | |
 Δ | − 0.07 ± 0.12* p < 0.05 | − 0.01 ± 0.18 | |
Glycemia | |||
 Week -4 | 98.81 ± 8.83 | 97.87 ± 10.11 | F = 4.858,p = 0.033 |
 Week 12 | 93.73 ± 15.73 | 103.20 ± 14.25 | |
 Δ | − 5.07 ± 14.14 | 5.33 ± 15.29 | |
AST | |||
 Week -4 | 18.76 ± 6.78 | 20.27 ± 5.92 | F = 4.275,p = 0.046 |
 Week 12 | 18.36 ± 5.16 | 15.93 ± 3.01 | |
 Δ | − 0.40 ± 5.95 | − 4.33 ± 5.60* p < 0.05 | |
ALT | |||
 Week -4 | 21.48 ± 12.27 | 24.80 ± 14.02 | F = 2.499, p = 0.122 |
 Week 12 | 18.60 ± 10.05 | 15.80 ± 6.32 | |
 Δ | − 2.88 ± 12.07 | − 9.0 ± 11.46* | |
GGT | |||
 Week -4 | 22.00 ± 12.14 | 20.67 ± 8.96 | F = 0.428, p = 0.517 |
 Week 12 | 18.16 ± 10.25 | 15.60 ± 4.76 | |
 Δ | − 3.84 ± 5.65* p < 0.05 | − 5.07 ± 5.89* p < 0.05 | |
Creatinine | |||
 Week -4 | 0.72 ± 0.11 | 0.69 ± 0.11 | F = 0.004, p = 0.949 |
 Week 12 | 0.72 ± 0.10 | 0.72 ± 0.11 | |
 Δ | 0.029 ± 0.12 | 0.027 ± 0.10 | |
Uric acid | |||
 Week -4 | 4.31 ± 1.38 | 4.41 ± 0.77 | F = 0.214, p = 0.647 |
 Week 12 | 4.37 ± 0.95 | 4.32 ± 0.94 | |
 Δ | 0.05 ± 1.03 | − 0.09 ± 0.68 | |
CRP | |||
 Week -4 | 4.32 ± 5.22 | 3.47 ± 2.54 | F = 2.026, p = 0.163 |
 Week 12 | 2.35 ± 2.33 | 3.96 ± 6.35 | |
 Δ | − 1.97 ± 4.13* p < 0.05 | 0.49 ± 6.71 | |
NLR | |||
 Week -4 | 1.82 ± 0.43 | 1.81 ± 0.48 | F = 1.108, p = 0.299 |
 Week 12 | 1.59 ± 0.41 | 1.87 ± 1.25 | |
 Δ | − 0.22 ± 0.48* p < 0.05 | 0.059 ± 1.17 | |
PLR | |||
 Week -4 | 131.61 ± 38.60 | 129.20 ± 43.10 | F = 1.624, p = 0.211 |
 Week 12 | 121.11 ± 28.58 | 130.44 ± 50.27 | |
 Δ | − 10.46 ± 29.04 | 1.24 ± 25.93 | |
CD3 + T lymphocytes | |||
 Week -4 | 64.29 ± 12.77 | 63.57 ± 10.59 | F = 0.772, p = 0.386 |
 Week 12 | 66.47 ± 16.38 | 70.50 ± 9.06 | |
 Δ | 2.17 ± 16.79 | 6.92 ± 13.79 | |
CD4 + T lymphocytes | |||
 Week -4 | 58.76 ± 12.18 | 62.71 ± 14.71 | F = 0.040, p = 0.843 |
 Week 12 | 62.70 ± 13.63 | 67.71 ± 12.49 | |
 Δ | 3.93 ± 17.02 | 5.00 ± 12.61 | |
CD8 + T lymphocytes | |||
 Week -4 | 30.76 ± 10.56 | 26.78 ± 11.50 | F = 0.018, p = 0.894 |
 Week 12 | 28.52 ± 12.27 | 25.21 ± 9.24 | |
 Δ | − 2.23 ± 14.26 | − 1.57 ± 14.20 | |
CD19 + B lymphocytes | |||
 Week -4 | 18.39 ± 10.14 | 15.78 ± 10.51 | F = 0.092, p = 0.764 |
 Week 12 | 17.33 ± 9.69 | 16.14 ± 6.92 | |
 Δ | − 1.06 ± 15.12 | 0.36 ± 10.77 | |
CD3- CD16 + CD56 + NK cells | |||
 Week -4 | 13.90 ± 8.26 | 15.78 ± 7.61 | F = 0.267, p = 0.609 |
 Week 12 | 12.67 ± 8.83 | 12.43 ± 9.56 | |
 Δ | − 1.22 ± 9.61 | − 3.36 ± 14.80 | |
Naïve CD4 + T lymphocytes | |||
 Week -4 | 22.61 ± 14.51 | 21.86 ± 10.09 | F = 0.103, p = 0.750 |
 Week 12 | 23.52 ± 13.65 | 20.79 ± 9.91 | |
 Δ | 0.90 ± 20.01 | − 1.07 ± 13.88 | |
Naïve CD8 + T lymphocytes | |||
 Week -4 | 28.34 ± 13.20 | 27.64 ± 13.44 | F = 0.405, p = 0.529 |
 Week 12 | 32.52 ± 15.24 | 27.50 ± 16.47 | |
 Δ | 4.18 ± 20.69 | − 0.14 ± 18.00 | |
Regulatory T cells | |||
 Week -4 | 0.92 ± 0.98 | 1.23 ± 1.46 | F = 0.007, p = 0.932 |
 Week 12 | 0.91 ± 1.50 | 1.29 ± 1.62 | |
 Δ | − 0.005 ± 2.01 | 0.06 ± 2.35 | |
Th17 lymphocytes | |||
 Week -4 | 0.45 ± 0.52 | 0.35 ± 0.31 | F = 1.415, p = 0.279 |
 Week 12 | 0.22 ± 0.17 | 0.95 ± 1.40 | |
 Δ | − 0.22 ± 0.66 | 0.60 ± 1.23 | |