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Table 2 Baseline characteristics of participants enrolled in VLCKD and HBD groups

From: Very-low-calorie ketogenic diet vs hypocaloric balanced diet in the prevention of high-frequency episodic migraine: the EMIKETO randomized, controlled trial

 

ALL

VLCKD

HBD

p-value

Partecipants (n)

N = 59

N = 30

N = 29

–

Gender, Female, n (%)

56 (94.9)

29 (96.7)

27 (93.1)

0.612

Age (years)

42.6 ± 11.5

41 ± 12.3

44 ± 10.5

0.361

Class of age (n)

 18–35

19 (32.2)

12 (40.0)

7 (24.2)

 

 36–50

21 (35.6)

10 (33.3)

11 (37.9)

 

 51 + 

19 (32.2)

8 (26.7)

11 (37.9)

0.402

Weight (kg)

88.6 ± 16.6

91.8 ± 16.0

85.3 ± 16.9

0.143

BMI, median (IQR)

31.6 (27.8–35.2)

33.65 (29.3–36.0)

29.0 (27.5–34.1)

0.051

WC (cm)

95.7 ± 12.6

98.3 ± 12.3

93.0 ± 12.4

0.112

HC (cm), median (IQR)

115.0 (109.0–124.0)

120.0 (110–126)

112.0 (106.2–119.2)

0.029

WHR

0.8 ± 0.8

0.8 ± 0.07

0.8 ± 0.09

0.960

Systolic BP (mmHg)

122.0 ± 14.0

126.1 ± 12.5

117.8 ± 14.5

0.026

Diastolic BP (mmHg)

81.3 ± 9.4

83.3 ± 9.0

79.5 ± 9.5

0.128

Heart frequency

76.4 ± 9.1

75.8 ± 8.8

77.2 ± 9.4

0.581

Comorbidity (n)

  ≥ 1

49 (83.1)

23 (76.7)

26 (89.7)

0.108

Comorbidity (n)

 Cardiovascular

5 (17.2)

–

5 (17.2)

0.052

 Hypertension

14 (24.1)

8 (27.6)

6 (20.7)

0.539

 Metabolic

24 (41.4)

10 (34.5)

14 (48.3)

0.286

 Gastrointestinal

24 (40.7)

11 (36.7)

13 (44.8)

0.524

 Respiratory

5 (8.5)

3 (10.0)

2 (6.9)

1.000

 ENT

1 (1.7)

–

1 (3.4)

0.492

 Urologic

3 (5.1)

1 (3.3)

2 (6.9)

0.612

 Rheumatologic

1 (1.7)

–

1 (3.4)

0.492

 Hematologic

2 (3.4)

2 (6.7)

–

0.492

 Neoplastic

1 (1.7)

–

1 (3.4)

0.492

 Gynecological

12 (20.3)

6 (20.0)

6 (20.7)

0.948

 Orthopedic

4 (6.8)

1 (3.3)

3 (10.3)

0.353

 TMJ dysfunction

1 (1.7)

1 (3.3)

–

1.000

 Trauma

4 (6.9)

1 (3.3)

3 (10.7)

0.344

 Psychiatric

10 (17.2)

5 (16.9)

5 (17.9)

0.905

Age migraine onset, mean ± sd

18.6 ± 9.3

19.5 ± 7.8

17.7 ± 10.8

0.462

Smoking, n (%)

15 (25.4)

6 (20.0)

9 (31.0)

0.330

Sport activity, n (%)

19 (32.2)

9 (30.0)

10 (34.59

0.713

Alcohol occasional consumption, n (%)

31 (54.4)

17 (60.7)

14 (48.3)

0.346

Previous pregnancies, n (%)

25 (44.6)

10 (34.5)

15 (55.6)

0.113

Menopause, n (%)

15 (27.3)

7 (24.1)

8 (30.8)

0.581

E/P therapy, n (%)

5 (8.9)

4 (13.8)

1 (3.7)

0.185

Quality of sleep, n (%)

 Poor

9 (26.5)

6 (31.6)

3 (20.0)

 

 Good

25 (73.5)

13 (68.4)

12 (80.0)

0.697

Aura, n (%)

10 (17.2)

4 (13.8)

6 (20.7)

0.730

Aura duration (minutes)

26.1 ± 21.4

23.7 ± 24.3

28.0 ± 21.7

0.789

MMDs (n/month)

13.2 ± 5.3

15.0 ± 5.6

11.3 ± 4.2

0.007

Monthly analgesic intake (n/month, %)

56 (96.6)

29 (100.0)

27 (93.1)

0.491

  1. BMI, body mass index; WC, waist circumference; HC, hip circumference; BP, blood pressure; ENT, Ear, nose and throat, TMJ, temporomandibular joint; E/P, estrogen/progestins; MMDs, monthly migraine days
  2. All values are presented as mean ± standard deviation or median (interquartile range, IQR). Differences were considered statistically significant when p was < 0.05. Significant p values are highlighted in bold